Luni, Aprilie 29, 2024

Exclusiv pentru Medici Veterinari

Curs Encefalopatii spongiforme transmisibile

  • Nivel: Începător
  • Durată:
Certificat:

Termină toate lecțiile și treci chestionarele cu un scor mediu de 70%

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Cursul prezinta bolile prionice la animalele domestice si salbatice. Sunt abordate Scrapia la oii capre, Encefalita Spongiforma a Bovinelor, Boala cronica cahectizanta a Cervideelor (BCCC), Encefalita transmisibila a Nurcilor (ETN),Encefalopatia Spongiforma a Felinelor, Encefalopatia Spungiforma a Ungulatelor Exotice. Cursul prezinta video manifestarile clinice si modul de stabilire a diagnosticului in bolile prionice ale oilor si bovinelor. Pentru cei intresati se poate consulta si descarca Regulile de buna practica GVP in stabilirea diagnosticului de EST.

Prionii (engl. proteinaceus infectious particles = particule proteice infectioase) constituie izoforma patologica a unei proteine normale – proteina prionica (PrP) – codificata de organismele gazda. In anumite conditii, aceasta proteina normala sufera o modificare post-translationala a structurii sale secundare, ceea ce ii confera noi proprietati, ca: rezistenta neobisnuita la actiunea factorilor fizici si chimici si transmisibilitatea similara agentilor infectiosi.

Bolile prionice ale omului si ale animalelor sunt consecinta acumularii in sistemul nervos central a izoformei patologice a proteinei normale. Ele sunt caracterizate prin :

  • perioada de incubatie lunga, de ordinul lunilor, cel mai adesea al anilor;
  • simptomatologie exclusiv nervoasa si evolutie clinica lenta, ce dureaza saptamani, cel mai adesea luni, uneori ani, dar intotdeauna cu final letal;
  • leziuni degenerative ale sistemului nervos central, reprezentate prin vacuolizari ale neuropilului si pericarionilor, necrobioza neuronala, astrocitoza si uneori acumulari (placi) de amiloid;
  • transmisibilitatea pe cale parenterala sau digestiva la aceeasi specie si la alte specii, in momentul in care se foloseste ca material infectant tesutul nervos, uneori si alte tesuturi recoltate din cazuri de boala;
  • absenta oricarui raspuns imun specific fata de agentul transmisibil, desi gazda isi pastreaza competenta imunologica fata de alte antigene.

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