Imunodermatologia la caine si pisica - dr. Borbil Septimiu

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PREFATA

”Abordarea si desfasurarea ampla a bolilor cutanate, cu implicatii imunologice, la caine si pisica este temerara. Complexitatea deriva din multitudinea aspectelor clinico-patologice si varietatea mecanismelor imune implicate. Asa cum precizeaza autorul, modelele animale asigura progresul medicinei umane, iar numeroase aspecte ale patologiei umane se regasesc la animalele de companie.
Numeroasele descoperiri recente ale cercetarii imunologice ingreuneaza cuprinderea detaliilor patogenetice si morfopatologice ale bolilor cu implicatii imune. in consecinta, este benefica dezvoltarea aspectelor teoretice ale imunologiei moderne, a caror cunoastere este indispensabila pentru intelegerea mecanismelor raspunzatoare de instalarea si perpetuarea bolilor cu substrat imun, la om si animal, importante pentru terapia acestora.
De la premizele amintite a pornit autorul in realizarea acestei monografii consacrate patologiei imune, la caine si pisica, extinsa pe parcursul a 700 de pagini. Densitatea informatiilor prezentate este neobisnuita si deosebit de dificila pentru un singur autor, ceea ce amplifica meritul doctorului Borbil.
Nu se putea realiza aceasta monografie fara imbinarea armonioasa a datelor recente din literatura de specialitate (imunologica si specific veterinara) cu experienta personala, in domeniul tratat.
Iconografia bogata, cu scheme si tabele explicative, numeroase chiar originale, la care se alatura imagini fotografice din experienta personala, amplifica intelegerea materialului prezentat, util atat studentului, cat si medicului veterinar.
Actualitatea terapeutica ocupa un loc important in economia cartii, aspect completat cu experienta proprie. Produsele farmaceutice elaborate in ultimii ani sunt prezentate cu discernamant, multe din ele fiind verificate in activitatea proprie.
Monografia constituie o realizare originala, cu importante elemente actuale, atat teoretice, cat si practice, utile unui domeniu important al medicinei veterinare. Personal, mi-a facut placere sa parcurg paginile de imunologie fundamentala si aplicata”.

Cluj-Napoca, 28 mai 2010

Prof.dr. Doru DEJICA
Catedra de Imunologie Clinica si Alergologie
UMF „Iuliu Hatieganu” Cluj-Napoca

Cuprins
1. Notiuni anatomice

1.1. Pielea – structura si functii
1.2. Jonctiuni celulare
1.3. Elementele celulare ale pielii
1.4. Anexele pielii
1.5. Vascularizatia pielii si circulatia limfei
1.6. Inervatia tegumentului
1.7. Mucoasele si semimucoasele
1.8. Sistemul neuroendocrin al pielii
1.9. Organele limfoide
         BIBLIOGRAFIE

2. Antigeni

2.1. Antigeni de suprafata
2.2. Antigeni de histocompatibilitate
2.3. Antigeni sechestrati
2.4. Superantigeni
2.5. Alergeni
2.5.1. Principalii alergeni implicati in practica alergologica
2.5.2. Alergeni recombinati
    BIBLIOGRAFIE

3.    Sistemul imun si atributele sale

3.1. Inflamatia
3.1.1. Inflamatia cronica
3.2. Complementul seric
3.3. Sistemul imun adaptativ
3.3.1. Limfocitele si baza celulara a imunitatii adaptative
3.3.2. Neutrofilele - structura si functii
3.3.3 Macrofagele si functiile acestora
3.4. Recuperarea postinflamatorie
3.5. Celule prezentatoare de Ag
3.6. Procesarea antigenului
3.7. Imunoglobulinele
3.7.1. Anticorpi monoclonali
3.8. Citokinele si functiile lor
3.9. Raspunsul imun
3.9.1 Moartea celulara si reglarea raspunsului imun
3.9.2. Toleranta imunologica
    BIBLIOGRAFIE

4. Elemente de imunopatologie

4.1. Starile de hipersensibilitate
4.2. Imunodeficiente
4.2.1. Imunodeficite primare
4.2.2. Imunodeficite secundare
4.3. Autoagresiunea imunologica
    BIBLIOGRAFIE

5. Semiologia cutanata
    BIBLIOGRAFIE

6. Diagnosticul dermatologic
    BIBLIOGRAFIE

7. Modalitati de diagnostic si atenuare a raspunsului imun in alergoze

7.1. Tehnici de imunodiagnostic
7.2. Aplicatiile serologiei in dermatologia animalelor de companie
7.3. Evaluarea subiectilor imunodeficienti
7.4. Metode de diagnostic specifice alergologiei
7.5. Hiposensibilizarea
    BIBLIOGRAFIE

8. Bazele terapiei dermatozelor alergice sau mediate imun

8.1. Imunosupresia
8.2. Medicatia adjuvanta
8.3. Terapia antibacteriana
8.4. Terapia antifungica
    BIBLIOGRAFIE

9.    Patologia cutanata indusa de starile de hipersensibilitate

9.1 Urticaria si angioedemul
9.2. Atopia canina
9.3. Atopia felina
9.4. Hipersensibilitatea de contact
9.5. Hiperensibilitatea alimentara
9.6. Hipersensibilitatea indusa de ectoparaziti
9.7. Hipersensibilitatea indusa de endoparaziti
9.8. Hipersensibilitatea hormonala
9.9. Hipersensibilitatea bacteriana si fungica
    BIBLIOGRAFIE

10.    Dermatoze datorate autoagresiunii imunologice

10.1. Lupusul eritematos
10.2. Dermatoze buloase autoimune
10.2.1. Complexul pemfigus
10.2.2. Dermatoze autoimune buloase subepidermice
10.3. Amiloidoza
10.4. Dermatomiozita familiala canina
10.5. Crioglobulinemia si criofibrinogenemia
10.6. Reactii medicamentoase cu manifestare cutanata
10.7. Eritemul polimorf
10.8. Sindroamele Lyell si Stevens-Johnson
10.9. Vasculita
10.10. Boala grefa contra gazda
10.11. Sindromul uveodermatologic canin
10.12. Condrita auriculara
    BIBLIOGRAFIE

11. Dermatoze idiopatice cu potentiale implicatii imunologice

11.1. Enteropatia imunoproliferativa a rasei Basenji
11.2. Alopecia areata
11.3. Pseudopelada
11.4. Psoriazis
11.5. Vitiligo
11.6. Dermatoza pustuloasa canina
11.7. Afectiuni caracterizate prin infiltrat eozinofilic sau plasmocitar
11.7.1. Pustuloza eozinofilica sterila a câinelui
11.7.2. Sindromul hipereozinofilic
11.7.3. Complexul granulomului eozinofilic felin
11.7.4. Granulomul eozinofilic canin
11.7.5. Dermatita (edemul) eozinofilica canina
11.7.6. Pododermatita plasmocitara felina
11.8. Afectiuni inflamatorii/granulomatoase nodulare neinfectioase
11.8.1. Granulomul/piogranulomul idiopatic steril
11.8.2. Adenita granulomatoasa a glandelor sebacee
11.9. Paniculita
11.10. Dermatozele lichenoide
11.11. Sclerodermia localizata
11.12. Celulita juvenila canina
11.13. Dermatita ulcerativa felina insotita de fibroza liniara subepidermica
11.14. Diverse alte afectiuni
11.14.1  Mucinoza idiopatica
11.14.2. Milium coloid
11.14.3. Plasmocitoza cutanata
11.14.4. Urticaria pigmentosa felina
11.14.5. Imunopatologia unghiilor
    BIBLIOGRAFIE
    

INDEX ALFABETIC al cartii

A

Ac. clavulanic 420, 427t, 589t, 636. 661
A-CAM 34
Acantoza 234, 343, 464, 547, 580, 656, 657
Acarus siro 115, 117, 498
Accidente posttransfuzionale 583
Acid arahidonic 144t, 146, 224t, 268, 274, 387f, 395, 462, 417
Acid folic (analogi) 219, 402
Acid lipoteichoic (LTA) 135, 138f, 461
Acidul miclofenolic 398
Acidul muramic 425
Acinetobacter spp. 419
Acinonyx jubatus 563
Acitretin 648, 660
Acizi grasi esentiali (AGE) 369t, 417, 418, 526-528, 535, 605, 648, 663, 669
Acorion spp. 439
Acrodermatita letala a rasei Bull Terrier 302
ACTH 56t, 77, 78, 191t, 235, 246f, 247, 392-395, 437
Actina 28, 30, 31, 32, 35-37, 39, 40, 44, 46, 48-50, 55, 59, 73, 164, 184, 185, 205, 227, 296, 488, 644
Actinomyces spp. 420
Activarea complementului 120, 151, 152, 189, 215, 216, 270t, 275, 279, 284, 356, 385, 449, 518, 569t, 575, 596, 598, 610
calea alternativa (properdinica) 139, 152, 153, 155f, 218, 283, 408, 422, 423, 546, 569t
calea clasica 189, 213, 423
calea lectinica 139, 152, 153, 155f, 190t, 284
Adapalen 414
Adenita granulomatoasa a glandelor sebacee 645
ADEPT 222
Adipocit 26, 27f, 137, 648
ADN bacterian 135, 138, 199
Adrenodoxina 78
Agamaglobulinemie 292, 456
x-linkata (sindromul Burton) 292, 293
Agenti oxidanti (O2-, H2O2, OH, NO) 140, 186, 280
Aglutinare (pasiva) 355
AHAI 189, 272t, 278, 279t, 306, 313, 398, 585t
AINS 375, 395, 397, 410, 448-451, 520, 579, 580, 582, 583
ALAT 396t
Alcaligenes spp. 420
Alergeni 97, 106-122, 214t, 230, 265, 269, 276, 277, 281, 337-340, 360, 365-380, 383, 412, 431, 434, 435, 448, 452-459, 462-464, 469f-474, 476-480, 482-491, 494, 497, 498, 599, 633
aeroalergeni 97, 107-109, 359, 360, 363, 374-376, 455t, 458, 470, 473t, 474, 634
aposi 378, 379t, 477, 478
chimici 107
de insecte 107, 497
de purice 108, 377, 474, 491-495
emulsionati 378
medicamentosi 107, 119
microbieni 107, 137
nativi purificati 106
plasma seminalis 107, 121
precipitati pe aluminiu 378, 478
recombinati 122, 124-126
trofoalergeni 107, 119, 359, 363, 365, 366, 371, 483, 633
Alergie 106, 107, 116, 118, 119, 122, 124, 158, 159, 229, 265, 267, 269, 272, 273, 292, 359, 365, 375, 376, 386, 413, 419, 448, 451t, 456, 465, 476-478, 484, 495, 490, 585t, 599, 635
Alilamine 435t
Alitretinoin 414
Alopecie 116, 120, 319, 224t, 339, 344t, 390, 399, 401-403, 439, 464, 465, 475, 476, 478, 488-492, 494, 496, 497, 504, 520, 527, 529, 533, 540-542, 570, 571, 576, 594, 601, 602, 607-609, 621-624, 629, 646, 647, 665

areata 314, 335t, 621-624

indusa medicamentos 583

Alotipie 213
ALPS 311
Alt a1 106
Alveolita alergica extrinseca 282
Amarolfina 439
Amfiregulina 232, 234
Amfotericina B 435t-437, 439
Amiloid 342, 562f, 563, 565, 567, 664
A 189, 190t
asociat (AA, reactiv) 563-565
Aβ 563, 565
P189, 190t, 563
Amiloidoza 167, 284, 300, 320, 562, 565, 567, 572, 641, 664
endocrina 567
familiala 565, 566t
imunogenica (AL) 564
localizata 566t
primara 565, 566t
senilitatii 567
sistemica reactiva 565
Amitriptilina 416, 583
Amoxicilina 119, 420, 427t, 578, 589t, 636, 661
Amperaza 357
Ampicilina 119, 120, 420, 451, 577
Amplicon 357
Amylinul 565
Anafilatoxine (C3a/C5a) 103, 147, 153, 270, 275, 298, 596
Anafilaxie 118, 123, 270, 274-277, 287, 375, 380, 450, 457, 474, 488
Anastomoze:
plexiforme 72
arterio-venoase precapilare 72
glomusuri Masson 72
ANCA 279, 594-596, 598, 602, 603
Anemie aplastica 605, 606
Anergia clonala 255
Anestezia cutanata 331
Angioedem (edem angioneurotic) 118, 120t, 298, 448, 449, 450, 451, 452, 488, 490, 577t, 580, 660
dobandit 450
ereditar (HAE) 448, 450-452
idiopatic 450
mediat de bradikinina 449
mediat de histamina 448
Angiogeneza 32, 59, 60, 62-64, 149, 188t, 192, 195, 196t, 227, 234, 237, 245, 570, 595, 625
Anhidride 123
Anisakis simplex 500
Anomalia Pelger-Huët 301
Anonichie 667t
Antagonisti ai opioidelor endogene 416
Anticoagulantul lupic 514
Anticorpi (Ac) 207, 335, 564
monoclonali (mAc) 30, 99, 108, 124, 168, 219-222, 302, 345, 349, 355, 361t, 363, 364t, 431, 565, 608, 635
Antidepresive 416, 582, 583
Antigen/i (Ag) 89, 94-100, 134t, 169, 279t, 285t, 286t, 361t, 584
allogeni (alloantigeni) 22, 96, 104, 177, 278, 295, 296, 364t, 605, 606
autohtoni 99
bacterieni 97, 127
completi 97
de histocompatibilitate (MHC-I, -II, -III, mHC) 81, 90, 99-105f, 162, 164, 166, 169, 171, 173, 176-179, 197-208f, 224t, 228-232, 240, 244, 245, 267, 287, 293, 294, 356, 400, 418, 425, 433, 457, 479, 569t, 587, 588, 606, 621, 626, 646, 669
endogeni 97, 134
Frossman 99
incompleti (vezi haptene)
nucleare extractibile (ENA) 522
proteic ribonuclear (Ro) 522
sechestrati 104
sialil Lewis–x 33, 297
singeni 99
virali 97
xenogeni 99
Antiglobuline 345, 347-349
Antihistaminice 121, 369t, 370, 375, 383t, 391, 397, 410, 411f, 413t, 416, 453, 472, 478, 489, 491, 494, 495, 498, 580, 582, 584, 631, 666
Antimalarice 409, 526
Antiserotoninice 410, 416
Aparatul pilo-sebaceu 64, 66
Apis melifera 117
Aplazia medulara a granulocitelor 300
Aplazia timica congenitala 294
Aplazia timica cu hipotrichoza a felinelor 302
Apoptoza 20, 30, 45, 59, 62, 71, 81, 82, 141, 167, 171, 176, 177, 180, 181, 188ttt, 192, 199-201, 222, 225, 227, 228, 230, 233, 243-245, 248-255, 289, 306, 312, 386, 401, 425, 437, 480f, 515, 516, 518, 520, 524, 543, 568, 571, 575, 579, 587, 588, 590-592, 595, 596, 602, 606, 608, 610, 622, 656, 664
Ardere oxidativa 186, 603
Arilfosfataza 272
Armoracia lapathifolia 349
Arterita cu celule gigant 593t, 594, 597
ArteritaTakayasu 593t
Arthemisia absinthum 109
ASAT 396t
Ascaris lumbricoides 149
Ascaris suum 200
Ascita 452, 521, 652
Ascomycota 429, 430
ASK 308
ASLO 308
Aspergiloza diseminata 299
Aspirina 526, 594t
Astm 109, 111, 122, 123, 136, 158, 247, 265, 266, 277, 278, 282, 377, 392, 400, 419, 448, 456, 458, 462, 464, 475, 476f, 478, 488, 505, 585, 593, 632, 634
Astrocite 47, 206, 304
Ataxia-teleangiectazia 295
Ateroscleroza 276
Atopie 76, 110, 114, 117, 121, 124, 218, 274, 277, 296, 334t, 343, 367, 380, 384, 391, 395, 419, 420, 431, 434, 453, 456-498, 504, 630, 633t, 636, 663
Atrofie 250t, 300, 333t, 369, 363, 401, 528, 571, 572, 580, 603, 607, 624, 646
Aureobasidium 431
Aurorafin 408
Aurotioglucoza 407, 408, 526, 589, 636
Autoanticorpi (AAc) 22, 31, 38, 41, 97, 104, 121, 206, 243, 253, 255, 278, 293, 294, 299, 304-308, 310-313, 323, 358, 359, 387, 403, 406,407, 448-450, 457, 472, 514-521, 525, 531, 532, 539, 540, 543, 545-548, 550-555t, 557-561, 568, 573, 574, 580-582, 587, 596, 600, 602, 603, 606, 621, 624, 626, 635, 647, 656
ANA 514-516, 521, 522, 524, 525t, 527, 568, 610, 612, 641, 658, 668
anti-C1q 519
anticardiolipidici 514
antifoliculari 621
antifotoreceptori 609
antigangliozide 609
antihistone 522, 524, 525t, 658
antiidiotipici 213, 517
antimelanina 609
antinucleozomi (ANuA) 517
Autoantigeni (autoAg) 97, 387f, 456, 516, 568, 580
Autofagia 248, 253, 628
Autofagozomi 20, 253
Autoimunopatii buloase subepidermice complexe 555t, 561
Avidina 352
Axul hipofizo-tiroidian 77
Azatioprina 104, 395-398, 408, 409, 525, 528, 534, 536, 540, 542, 553, 555, 559, 561, 574, 591, 605, 610, 645
Azithromicina 427t
Azole 435t--437, 440
Azurocidina 184

B

B-1H-globulina 548
Bacillus cereus 421f
Bacteroides spp. 420
BALT 90
Bariera fizica 132
Basidiomycota 429
BCG 148, 161t, 294, 583
Bet v1 106, 124
Betametazon 387t, 388t, 391t, 392, 527
Bexaroten 414
Bilirubina totala 396t
Biopsia cutanata 391, 494, 501, 527, 533, 590, 592, 610, 629, 631, 632, 665, 666
Blastomyces dermatitidis 286t, 431, 436
Blatella germanica 117
Blefaroconjunctivita
Blocada β-adrenergica 459
Blomia tropicalis 498
Boala:
Addison 676
Alzheimer 564, 565
Behçet 293, 595
Creutzfeldt–Jakob 563
Crohn 456, 625
cronica granulomatoasa 296
Darier 38, 415
Grawes 289f
Hirschprung 484
Kawasaki 151, 593t, 595, 597
lanturilor grele 168, 302
ochilor albastri 281, 285t
Ofugi 323
serului 278, 282, 285t, 439, 576, 594t
Whipple 649t
Bordetella pertusis 269
Borrrelia burgdorferi 175, 658
BP180NC16A 548
BPI 182t, 188
Brachionichie 667t
Bradikinina 75, 147t, 269, 271, 415, 449, 450
Bronhopneumonia prin aspiratie 571
Bronhopneumopatia eozinofilica 458
Bronhospasm 270t, 276
Bula (flictena):
sub tensiune 323
flasca 323
multiloculara 323
uniloculara 323
subcornoasa 323
intramalpighiana 323
subepidermica 323
Bulge region 52

C

Caderine 27-30, 33-35, 38, 39, 56
caderina E 39, 30, 204
caderina N 30, 33
caderina P 30
caderina T 28, 30
CADESI 395, 401
Calcineurina 165, 400
Calicivirus 305, 313, 404, 469, 600
Calreticulina 31
CAM 25, 27-30, 32-35, 82, 99, 100t, 132, 171, 172, 182t, 191, 196, 198, 203, 223, 228, 265, 287, 361t, 411, 420, 435, 449, 458, 479, 518, 519, 570, 595, 596, 606, 634
Can f1 106, 114
Canale ionice 48, 49, 57
Candida albicans 111
Captopril 532, 539, 542, 583
Carbapenemi 119
Carcinom 88, 178, 272t, 311, 320, 321, 337, 415, 533, 544t, 59, 607, 630, 633t, 635, 644, 652, 656, 657, 665
Carebastina 411, 412
Catelicidine 188t, 454, 461
Catenine 30, 31, 35, 39
Catepsina 181, 182t, 187, 270t, 361, 362, 569t, 663
CDR 105, 170, 210, 211f, 221
CEACAM 1 34
Cefadroxil 119, 427t, 582, 636
Cefalexina 119, 120t, 427t, 577t, 589t
Celule
endoteliala (EC) 24, 26, 30, 32-35, 46, 60-62, 90, 132, 386
Merkel 16f, 17, 26, 56, 57, 74, 75, 90, 351t, 628
stem (epidermica) 18, 41, 43, 51, 52, 57
LE (lupica) 522, 527
de memorie 161, 162, 166, 167, 252, 256
dendritice (DC) 28, 52, 79, 80, 82, 86, 89, 110t, 110, 132-140, 143, 145, 146, 158-160, 164, 167, 171-175, 183, 187, 188, 194, 197-206, 208, 226-228, 230-233, 236-238t, 247, 243-245, 247, 266-269, 290, 304, 351, 386, 418, 433, 455, 456, 459, 474, 480f, 481, 497, 501, 551, 570, 595, 600, 621, 624-626, 646, 647
epiteloide 150f
gigant 139, 148, 149, 203, 230, 288, 341, 378, 429, 533, 578, 582, 583, 593t, 5¸597, 660, 644, 645, 650-652, 654
K 178, 213
Kupffer 89, 137-139, 193
Lak 180
Langerhans 15-17, 21, 26, 29t, 30, 43, 52, 74, 88, 89, 113, 133t, 148, 158, 194, 197-205, 227, 242, 247, 286, 297, 345, 372f, 400, 433, 453-471, 474, 479-483, 515, 579, 587, 595, 599, 607, 621, 625, 628, 644, 656
M 82, 83
mononucleare 61f, 122, 138, 157, 177, 178, 202, 203, 205, 227, 231, 237, 267, 277, 279, 280, 282, 287, 300, 305, 306, 353, 418, 452, 458, 46664, 479, 492, 497, 503, 518, 527, 543, 547, 554, 558, 582, 599, 628, 631, 636, 639, 644, 651, 667-669
multipotente 60, 157
NK 33, 100t, 103, 134t, 179, 180, 187, 236, 238t, 304
NKT 174, 175, 517
NS 245
polimorfonucleare (PMN) 33. 62, 83, 84, 157, 158, 181, 205, 267, 269, 281, 290, 296, 298, 200, 408, 518, 578, 579, 581
prezentatoare de Ag (APC) 82, 100t, 102t-104, 133t, 160, 162, 164, 168-176, 196, 197, 199, 204-208, 231, 242, 244, 247, 253, 255, 265, 266, 312, 376, 406, 453-455, 461, 462, 472, 518, 575, 587, 606, 624-626t
progenitoare 42, 57, 156, 159, 206, 224t
Schwann 24, 56, 297, 351t
Touton 148
tranzitorii de amplificare 51
unipotente 157
celei de a treia clase 157, 177
santinela 135, 136, 139, 140, 144, 192, 193, 196, 199
Leydig 148
Tart 522
Celulita (eozinofilica, juvenila canina) 324, 334t, 420, 452, 468, 630, 639, 660, 661
Cenestopatie 331
Chapel Hill (criterii de clasificare - vasculite) 593t
Chemoatractanti 159, 184, 187, 192, 224t, 230, 231, 423, 598, 634
Chemokine 59, 62, 86, 115, 132t, 133t, 140, 143f-147t, 158, 159, 173f, 176, 182, 191, 199, 200, 223, 225, 226, 231, 232, 235-238t, 269, 271, 273, 287, 412, 462, 468, 480, 519, 568, 606
Chemotaxie 110t, 147t, 154t, 182, 184, 224, 238, 300, 301, 413, 423
Cheyletiella yasguri 340
Cheyletus eruditus 498
Chist 325, 330, 333t, 502, 651, 654, 662t
Chitridomycota 429
Chloroquina 409
Chrysosporium 431
Cicatrice 324, 327, 528, 555t, 602, 650, 651, 653
Ciclofilina 112, 400
Ciclofosfamida 398, 399, 408, 525, 534, 542, 583, 605, 634
Ciclooxigenaze 58, 146, 274t, 395, 417, 460
Ciclopirox 439
Ciclosporina 104, 400, 401, 402, 527, 542, 543, 577, 599, 605, 607, 608, 610, 624, 625, 646, 648, 660, 663
Ciclul Krebs 81
CID (coagulare intravasculara diseminata) 320, 573, 576, 603, 652
Cimetidina 120t, 145, 146, 410, 577t, 582
Ciptoheptadina 413, 416
Circulatia limfatica 73, 194
Citocrom P450 575, 576
Citodiagnostic 333t, 341
Citokine 16, 42, 52, 58-63t, 74, 81, 82, 99-102t, 105, 115, 122, 132t, 136, 138-149, 159, 161, 164-166, 171-176, 180, 182, 188f-193, 195, 197—200, 206, 208, 218, 229-233, 235-239, 240, 244-249, 266-268, 271t, 274t, 275, 289, 306, 307f, 310, 312, 361, 362, 376, 385, 386, 395, 402-405f, 412, 413, 418, 426, 428, 433, 435, 450, 454t,-459, 462, 468, 479-481, 486, 492, 500, 501, 504, 518, 519t, 548, 549, 568, 579, 584, 587, 595-599, 603, 606, 607, 610, 522, 625, 626, 632-634, 638, 652, 662
Citomegalovirus 594, 621
Citometria în flux 52, 103, 347, 361t, 471, 602
Citoschelet 17, 27, 28, 31, 35-38, 40, 41, 43, 44, 46, 49-51, 55, 56, 181, 199, 227, 251, 252t, 345, 520
c-Kit 56, 159, 160t, 271
Clarithromicina 427t
Claudina 35, 36
Clearence 153, 154, 184, 193, 194, 298, 516, 518, 520
Clemastine 391, 413, 577t
Clindamicina 420, 427t
Clomipramina (anafranil) 416
Clone interzise 253, 311
Clonotip 166
Clorambucil 398, 399, 525, 528, 534, 536, 542, 553, 555, 605, 624
Cloramfenicol 120t, 279, 304, 420, 427, 577t, 589
Clorfeniramin 413t
Clostridium spp. 419, 420
Clotrimazol 438
Cluster of differentiation (CD) 99
Coagulaza B (ClfB) 422, 423
Cobalt 106, 107, 122, 123, 481, 583
Coccidioides immitis 431, 436, 438
Coiled-coil 49, 50
Colagen 15, 21-27f, 32, 40f, 41, 57-60f, 62, 72, 73, 84, 141t, 148, 149, 152, 193, 195, 196t, 228, 233, 234, 278-282, 328, 335t, 351t, 372t, 386, 408, 413, 468, 491, 496, 499, 515, 529, 531t, 545-551, 553-562, 574, 582, 587, 590, 597, 603, 612, 625, 628, 634, 637, 640, 658-660, 663, 664
Colectine 188, 189
Colesterol 45f, 78, 98, 389, 396t, 415, 417, 459, 644
Colhicina 559
Collie nose 527
Colon iritabil 484
Comedon 325, 339
Commelina diffusa 481
Compartiment de diferentiere 43
Compartiment germinativ 43
Competitia antigenica 242, 243
Complement (C) 120, 121, 132t, 138, 144t, 147t, 151-155f, 185f, 190t, 193, 210, 279t, 291t, 297, 298, 300, 345, 355, 356, 360, 364t, 448, 450, 568
Complement total hemolitic (CH50) 300, 301, 360, 364
Complex proteolitic (C4b, C2b, C3b) 152
Complexe imune (CI) 142, 285t, 298
Complexe imunostimulatoare lipozomi-plasmide-ADN 379
Complexe limfoglandulare 82
Complexul CD21/CD19 165f
Complexul granulomului eozinofilic felin 113, 116, 377, 475, 489. 490, 634
Compusi antihemostatici 63t
Compusi prohemostatici 63t
Condrita auriculara 612
Condrocite 34, 57, 142t, 226
Condroitinsulfat 147
Conexine (Cx) 41, 42
Conexon 41
Conidie 429, 430
Conidiofor 430
Constanta de afinitate 96
Convertaze 151, 283, 298, 423
Cordoanele Billroth 88
Corpusculi:
Hassal 80
Odland 19f
Russel (celule Mott) 87, 641, 642t
senzitivi 74, 76
Wiebel-Palade 60
Cortizon 386, 387t, 388t, 391t, 392
Corynebacterium minutissima 438
CRD 124
Creatinina 333, 389, 396t, 602
CRH 77, 78, 191, 246f
Criofibrinogen 528, 572-574
Crioglobuline 151, 168, 284, 320, 448, 451, 452, 465, 572t-574, 593t, 594t, 598, 603
Crioprecipitat 572, 574, 585t
Crisoterapie 407, 526, 534, 542, 641
Cristale Charcot-Leyden 274t, 539
Crossidiotipul WA-mRF 573
Crossreactivitate 96, 99, 104, 117, 119, 122, 223, 293, 308, 370t, 379, 431, 474, 488, 491
Crusta 196t, 325-329, 333t, 339, 343, 396t, 427, 464, 468, 478, 482t, 488, 499, 521, 524-527, 533, 540-542, 546, 547, 551, 554, 560, 601, 602, 646, 647, 648, 661
Cry j1 110
Cryptococcus neoformans 286t, 431, 436, 438, 439
CTACK 115, 237
Ctenocephalides spp. 106, 109, 340, 368t, 494
CTLA4 243
Culicidae 491
Culturi
bacteriene 427
fungice 111, 340, 431
Cuticula 67, 500
CVID 228
Cyn d1 109

D

Dapsona 408, 409, 526, 534, 535, 542, 555, 558-561, 579, 605, 612, 629, 631, 634
Defensine 140, 147t, 182t, 184, 187, 188, 192, 199, 424, 454-456
Deficit/e
de α1-antitripsina 649
functiei neutrofilelor la rasa Pinscher 301
C3 si C5 298
C6, C7 si C8 298
caii alternative 298
de adenozindeaminaza 295
de ingestie/fagocitare a bacteriilor 297
functiei de adeziune celulara-1 (LAD-1) 297
functiei de adeziune celulara-2 (LAD-2) 297
purin-nucleozid fosforilazei 296
stadiilor initiale ale activarii C (C1,C2,C4) 298
Deflazacort 391t
Deletie (antigenica, clonala) 81, 96, 166, 200, 242, 253, 254, 256, 306, 307f
Demodex spp. 150f, 305, 318, 325, 340, 469, 477t, 498
Dendrite 55, 197, 198, 134, 351t
Dendrocite 204, 588, 592, 644
Depo-Medrol 390
Derm (papilar, reticular)
Dermatita:
eozinofilica canina 639
alergica de contact (DAC) 389, 411, 413, 456, 478, 479, 483, 527
atopica (DA) 113, 188, 218, 411, 413, 453, 456, 462, 464f, 650
de iritatie 478
eozinofilica edematoasa a cainelui 630t
faciala cu herpesvirus a felinelor 630t
granulomatoasa sterila juvenila 643t
histiocitara lichenoida 610
Dermatita venenata 577
Dermatofitoza 327, 335t, 337, 341, 495, 505, 541, 543, 571, 590, 647, 658
Dermatofiti 39, 112, 318t, 340, 341, 428, 430f, 431, 436t, 438, 439, 462, 469, 477t, 505
Dermatografism 370t, 451t, 452
Dermatomicoza 333t, 428, 438
Dermatomiozita familiala canina (DFC) 413, 568, 570-572
Dermatopatia ischemica
Dermatophagoides farinae (Der f1)
Dermatophagoides pteronyssinus (Der p2)
Dermatoza buloasa cu IgA liniare (LAD) 555, 559-561t
Dermatoza pustuloasa canina 628, 631
Dermatoze lichenoide 350, 471, 580, 655, 656, 657, 658
dermatita Blaschko 655t, 657
erythema dyschromicum perstans 655t
GVHD lichenoid 655t
keratoza lichenoida 655t
lichen aureus 655t, 657
lichen nitidus 655t, 657
lichen planopapilaris (peripapilar) 655t
lichen planus 655t
lichen striatus 655t, 657
mycosis fungoides lichenoida 655t
Desaturaza 417, 460, 461f
Desensibilizare (celulara, umorala) 108, 359, 363-367, 375, 378, 383t, 406, 471, 478
Desloratadina 412
Desmocalmina 37
Desmocolina 38, 30, 31, 37, 38, 532, 535
Desmogleina 38, 30, 31, 37, 38, 532, 549
Desmoplakina 31, 38, 532, 543, 544, 548, 587
Desmozomi 17, 19, 20, 22, 28, 30, 31, 35-40, 45f, 47, 52, 53, 57, 69, 197, 279t, 323, 531-535, 543, 544, 664
Determinant antigenic 95, 210, 530
Deuteromycota 429
Dexametazon 153, 387t, 388t,-392, 542, 636, 641, 661
Dextran-sulfat 407
Diabetes mellitus (diabet zaharat juvenil) 272t, 566t, 626
Diapedeza 183, 202, 423, 449, 479, 595
Diascopie 318-321
Dieta de eliminare 342, 365t-367, 467, 469f, 488-491, 498, 663, 669
Dietilcarbamazina 577t, 589t
Difenhidramina 146, 413t
Diferentiere 16-20, 22, 28, 30, 33, 42, 43, 44, 46, 48, 50-52, 57, 59, 68, 71, 78, 83, 87, 125, 146, 157, 158, 160, 162-165, 168, 171, 176, 177, 180, 199, 201, 209, 215, 223, 233, 235-237, 240, 241, 247, 250, 252, 265, 269, 271, 293, 295, 304, 319, 385t, 393, 414, 415, 518, 563, 597, 648, 665
Difloxacin 427t
Dipentena 589t
Dipylidium caninum 495
Dirofilaria spp. 284, 343, 355, 502
Disgenezia reticulara 295, 296
Displazia timica (sindromul Nezelov) 294
Displazie foliculara 334t, 662t
Dolicho vespula maculata
DOPA 54, 342, 627
Doxepina 416
Doxiciclina 669
Drosophyla melanogaster 136
Duble coiled-coils 50

E

ECC (componente precoce) 152
Echimoze 319, 339
Ecografia cutanata 343
Econazol 435, 438
ECP 110t, 141, 272, 274t, 275, 361t, 550, 361
Eczema 30, 290, 322, 328, 373, 384t, 454, 470f
Edem 118, 145, 196t, 228, 235, 250, 269, 270t, 272t, 276, 280-282, 320, 323, 324, 331, 334t, 343, 380, 386, 389, 401, 411, 448, 464, 483, 494, 520, 524, 538f, 547, 548, 554, 574, 576, 580, 581, 586, 587, 590, 594, 596, 599, 601, 607, 609, 632, 637, 639, 640, 650, 652, 657, 659, 665, 668
Editarea receptorului 254
EDN 273, 274, 364
EGF 59, 62, 232, 233, 234
Elastaza 181, 182t, 184, 187, 192, 195, 205, 361t, 385, 549, 550, 596, 598, 650
Elastina 22, 24, 26
ELISA (sandwich, macELISA) 112, 116, 220, 348, 349, 352, 359, 361-365t, 375, 449, 471, 477, 487, 491, 502, 522, 550-555, 558, 559t, 561, 602
Endarterita obliteranta (hiperplazia intimei) 595, 597, 604t
Endoteline 56, 62, 140, 235, 236
Enrofloxacin 427t, 636
Entactina 22
Entamoeba histolytica 501
Enteropatia imunoproliferativa a rasei Basenji 304, 621
Enterotoxina A (SEA) 121
Envoplakina 31, 38, 44, 45, 531, 543
Eotaxina 160, 271, 634
Eozinofil 26, 33, 65, 87, 101, 110t, 113, 136, 142t-149, 158, 159, 172, 206, 213, 218, 224t, 226, 229-232, 237, 238t, 245, 266, 267, 269-276, 280-282, 288, 289f, 323, 341, 361t, 376, 377, 400, 408, 411, 426, 449, 450-458, 468, 471, 474, 476, 478, 483, 489, 491, 494, 496-502, 533.536, 541-551, 554, 558, 561, 587-583, 596, 599, 600, 604t, 623, 624, 630-640, 650, 654, 661, 662, 666, 668, 669
Epi p1 106
Epiderm 15-22, 25, 26, 30, 35, 37, 40-45, 52, 56, 57, 59, 65, 66, 69, 70, 74, 77, 133t, 158, 188, 197, 198, 203, 228, 233, 234, 235, 318t, 320-324, 328, 342, 343t, 417, 419, 535, 454, 455, 458, 460, 480t, 497, 504, 515, 516, 530, 531, 535, 540, 544, 545, 547, 579, 580, 583, 586-592, 599, 625, 627, 628, 630, 635-637, 640, 647, 656-659, 663, 664
Epidermoliza buloasa (distrofica, simplex, hemidesmozomica, castigata – EBA, Epidermolysis bullosa) 323, 350, 531, 555t, 556, 557, 559, 562
Epinastina 411t, 412t
Epitopi 94-99, 102t, 106-108, 124-126, 160, 166, 173, 207, 210, 240, 242, 255, 308, 310, 312, 353-355, 376, 377, 380,543, 552, 560, 561, 575
criptici 306, 312
Epoxirezine 123, 481
Eritem (morbiliform, scarlatiform) 319, 320, 577, 578, 582
Eritem polimorf (erythema multiforme, EP) 120, 335, 452, 529, 555, 577t, 586
Eritrocite 554t, 558t
Eritrodermie 120t, 464, 521, 540, 577t, -581, 607, 647
Eritromicina 420, 427t, 553, 589
Erlichia canis 168
Eroziune 324, 329, 333, 339, 475, 629
Eruptie 279t, 329-331, 475, 488, 490, 491, 495, 503, 514, 516, 524, 528, 529, 539, 558, 561, 577t, 579, 581, 582, 594, 607, 629, 649, 657, 666t
Eruptie fixa 120t, 331
Eruptii fotoalergice/fototoxice 580
Erythema nodosum 578, 649t-651, 654
Escara/sfacelul 327
Essentiale forte 397
Etenoxid 123
Eteroantigeni 96
Etilendiamina 106, 123, 583
Etretinat 414, 415, 648
Exantemul fix medicamentos 579, 581
Excludere clonala 255
Excoriatia 324
Excretia apocrina 65
Expansiuni iederiforme 74
Extracte alergenice 374, 378
Ezrina 519

F

Factori de crestere 48, 58, 63t, 133t, 158, 159, 231, 235, 271t, 419, 597, 627
Factori reumatoizi (RF) 212, 308, 514, 51s, 568, 573t
Factorul H 422, 423
Factorul plachetar-3 522
Factorul VIII (von Willebrand) 60, 62, 63t, 190, 585t
Fagocite sinusale 84
Fagocitina 181
Fagocitoza 43, 151-155, 158, 177, 182-189, 191-195, 199, 203, 205t, 210, 213, 216, 228, 231, 250, 272, 277-279t, 285, 288, 296-298, 300, 301, 304, 505, 308, 386, 422-425, 570, 582, 652
Fagolizozom 186, 434
Fas 177, 178, 245, 252, 306, 307f, 312, 579, 592, 602, 656
Fasciculele Goll si Burdach 76
FcγR (I-III) 165, 175, 176, 178, 179, 184, 189, 191, 193, 199, 217, 230, 242, 243, 268, 280, 289f
Febra medicamentoasa 576
Fel d1 106, 113, 114f, 125, 634, 635
Fenacetina 278, 594t
Fenilbutazona 279, 532, 599t
Fenobarbital 399, 583, 599t
Fenomenul Arthus 280. 281, 282, 285t, 287, 371, 505, 596, 598
Fenomenul Köbner 595
Fenotiazinice 580, 582, 594t
Feritina 189, 190t
FGF 56, 63, 176, 224t, 233, 234-236
Fibre de reticulina 24, 26
Fibre elastice
Fibrilina 24, 25
Fibrina 32, 147, 272, 657
Fibrinogen 22, 32, 60, 136, 144t, 147, 184, 190, 386, 422, 423, 528, 572, 573, 585t, 598
Fibrinoliza 63t, 147
Fibrinopeptida B 184
Fibroblast 22-27f, 29t, 30, 33, 42, 46, 49, 52, 53, 57-60, 64, 74, 78, 84, 90, 101t, 141, 142t, 143, 146, 148, 148, 189, 195, 196t, 206, 224t, 226-238t, 251, 288, 328, 351, 372t, 386, 393, 402, 415, 454, 644, 660, 662-664
Fibrocit 22, 57, 73, 84, 90, 221
Fibronectina 21, 22, 24, 25, 31, 32, 34, 58-60, 62, 160t, 193, 282, 313, 362t, 413, 420, 422, 423, 471, 479, 515, 597
Fibrosarcom inflamator 544t
Filagrina 20, 44, 45, 51, 453, 459
Filamente intermediare 40f, 43, 46f, 47, 49-51, 55, 197
Filensina 47
FIP 227, 404, 600
Fipronil 494, 577
Fistula (traheoesofagiana) 321, 325t, 341, 344t, 400, 402, 420, 484, 653
Fisura (ragada) 324
Fitofotodermatita 580
Fitohemaglutinina 363, 364t
FIV 198, 226, 304, 305, 350, 365, 401, 404, 431, 436, 439, 469, 576, 600, 612, 640
Fixarea complementului 355, 548, 550
Flucitozina 435t, 437-439, 577
Fluconazol 435t, 436, 438, 439, 577
Fluorocromi 347
Flumetazon 388, 391t, 577t
Fluorouracil 438, 516, 583
Fluoxetina 416, 583
Foliculita eozinofilica nazala si furunculoza cainilor 630
Foliculita 118, 318, 323, 334t, 339, 343, 344, 415, 426f, 452, 464, 468-470, 475, 477, 482,489-491, 493, 494, 521, 541, 543, 571, 582, 586, 590, 599, 603, 622, 624, 629-631, 637, 646-648, 658
Folinat de calciu 403
Formaldehida 97, 106, 123, 481
Fosfataza acida 58, 106, 351t
Fosfatidil-serina 195
Fosfoglucomutaza 119, 487
Fosfolipaze 106, 117, 146, 164, 165, 182t, 255, 268, 274t, 277, 287
Fotoperioada 247
Fotosensibilitate 515, 524, 525, 529, 580, 582
Fototerapia PUVA 550
Fractalkina (CX3CL1) 143, 144, 237
Fungi:
dimorfici 429-431
filamentosi 429, 430
levuliformi 429
Fungi alergogeni atmosferici 107
Alternaria spp. 111, 281, 368t, 431
Aspergillus spp. 111, 112t, 148t, 281, 291, 299, 368t, 428, 431, 436, 439, 469
Cladosporium spp. 111, 281, 431, 439
Mucor spp. 111, 431
Penicillium spp. 111, 281, 368t, 398, 431
Fusobacterium spp. 420, 421f

G

GALT 90, 244, 291
Galactozamina 213
Gamopatii 167, 168
Gastrita (gastroenterita) eozinofilica 632, 633
GATA-3 146
G-CSF 159, 225, 232, 245, 651
Gene 213, 221, 227, 237, 254, 310, 414, 458, 515, 570
Gentamicina 120, 420, 558, 577, 589
Genul Rhus 123
Ginkgo biloba 628
Glande
Harder 90
Meibom 66
Moll 66
sebacee 16, 17, 51, 64, 66, 69, 74, 77, 113, 188, 325, 334t, 336t, 415, 455, 483, 586, 603, 623, 624, 628, 630, 631, 645-648, 661, 664, 665
specializate 64
sudoripare 15, 17, 25, 26, 51, 64-66, 72, 227t, 351t, 456, 463, 465, 529, 538t, 603, 623, 656, 661
Zeis 66
Glicocalix 17
Glicoproteina BM-600 22
Globuline 94, 209, 396t, 534, 551, 585t, 629,631, 654, 661
Glomerulonefrita membranoproliferativa (MPGN) 282-285
Glucocorticoizi 31, 69, 78, 234, 246, 247, 290, 297, 305, 369t, 371, 380, 383t-393, 395, 397, 398, 400, 401, 408, 410, 414, 438, 468, 472, 483, 488, 494, 496, 499, 501, 524, 525-527, 534, 542, 543, 553, 574, 584, 586, 591, 593, 604, 605, 608, 610, 624, 630-632, 636, 639, 640, 644, 648, 661, 663, 666, 669
Glycyphagus domesticus 117, 498
GM-CFS 232, 459
Goma 321
Granule lamelare 44, 45
Granulocite 29t, 34, 81, 88, 90, 100t, 103, 157, 158, 179, 181, 175, 224t, 232, 269, 300, 301, 304, 305, 351, 455, 550, 633
Granulocitopatia Setterului irlandez 300
Granulom (eozinofilic) 148, 149f-151, 202, 288, 296, 320, 322, 336t, 344, 393, 468, 475, 477, 478, 491, 494, 495, 578, 582, 594, 599, 604t, 633, 635-638, 643t
Granule Birbeck 197, 199, 202, 204
Granulomatoza Wegener 151, 593t, 594t, 597, 502, 604t
Granuloma annulare 649t
Granulomul/piogranulomul steril idiopatic 643
Granulozinele 188
Griseofulvina 120t, 435, 436, 439, 580
Grup imunodominant 95
Grupare carrier 94, 106, 113, 122, 190, 255
Grupare peniciloil 98
GGT 396t
Glicemie 396t, 397t

H

Haemophilus influenzae 269
Hamelia spp. 477
Haptena 94, 95, 97-99, 106, 107, 122, 123, 277, 278, 281, 286t, 348, 449-481, 575, 576, 579, 581, 591
Haptoglobina 189, 190t, 388
Haustori 429
Hemaglutinarea virala si inhibitia sa 355
Hematom 604t, 651
Hematopoieza ciclica a cainelui 301, 344, 565
Hemidesmozomi 17, 21-23, 32, 35, 38, 40, 41, 53, 197, 536, 548, 549, 552, 555-557
Hemoglobinuria paroxistica nocturna 298
Heparina 60, 62, 63t, 139, 145, 147, 226, 233, 267, 269, 270, 274, 275, 361, 536, 661
Hernia hiatala 484
Herpesvirus 178, 313, 404, 588, 600, 630
Hev b1 122t
Hevea brasiliensis 122t
HGF 56, 235, 236
Hibridoame 168, 220, 345
Hidrocortizon 369, 387t, 388t, 390-393, 527
Hidrolaze acide 58, 181, 182, 187, 270t, 362t, 385
Hidroxichloroquina 409
Hidroxizin 391, 413t, 640
Hife 341, 429, 431
Himenoptere 106, 117, 118, 370
Hipercomplementemia 298
Hipercorticismul 298, 389, 392, 396, 387t
Hiperkeratoza 302, 321, 333t, 433, 465, 482, 520, 547, 580, 621, 646, 647, 656, 659
Hiperonichie 667t
Hiperplazie 69, 87, 88, 319, 320f, 334t, 341, 360, 401, 433, 478, 496, 539, 547, 570, 579, 580, 590, 656
Hipersensibilitate:
alimentara 76t, 118, 334t, 465, 478, 483, 486, 489, 490, 493, 495, 496, 593, 599t, 630, 663, 668
cutanata bazofilica 287, 495
stafilococica 281
tipul I 122, 265, 274, 489, 490, 580, 596
tipul II 278, 279, 573, 596
tipul III 279, 280, 282, 285, 449, 496, 518
tipul IV 285, 286t, 371, 372, 449, 496
tipul V 288
tipul VI (ADCC) 178, 213, 223, 228, 232, 288, 289, 515, 549, 626, 663
Hipocomplementemia 298, 450, 596, 598, 599
Hipoderm 16, 22, 25, 26, 71f, 72, 74, 321, 324, 325, 328, 342, 343, 373, 449
Hipogamaglobulinemia tranzitorie 294
Hiposensibilizare (ASIT) 375-379t, 383, 469t, 470, 472, 476, 478, 483, 485, 494, 495, 594t, 599t
Hippeastrum vittata 481
Histamina 32, 60, 62, 75-77, 117, 119, 124, 139, 140, 144t-147t, 153, 154, 158, 159, 181, 188t, 201, 214, 218, 224, 231, 238, 267, 269-276, 287, 361t, 369-371, 380, 386, 409, 410, 415, 448-450, 460-463, 477, 484-486, 494, 549, 576, 596
Histiocit 22, 26, 73, 84, 88, 101t, 139, 148, 177, 203-205, 351t, 378, 458, 471, 551, 571, 578, 579, 581, 582, 583, 587, 623, 624, 637, 644, 645, 649t-652, 656, 665, 669
Histiocitoza 88, 101t, 177, 202-205, 344t, 408, 643, 644, 649t
Histone 123, 269, 359, 516, 522, 524, 531t
Histoplasma capsulatum 286, 434, 436
HLA 110, 238t, 309, 312t, 362t, 411t, 412, 529, 535, 569t, 606, 655
Holoclone 51

I

Iarba de Bermuda (Cynodon dactylon) 109, 379
IBD 299, 403
ICAM 29, 33, 34, 36, 60, 63, 100, 173, 182, 183, 192, 200, 203, 224t, 226, 235, 351t, 361t, 411, 418, 449, 457, 459, 479, 516, 587, 596, 597, 600, 606, 658
Idiosincrazie 118, 119, 483
Idiotip 177, 213, 243, 516, 517
IGF-1 191, 234, 235
Imidacloprid 494
Imipenem 119
IMPH-350/IMTR-350 407
Impulsurile tactile (discurile lui Merkel, corpusculii Ruffini, corpusculii Pinkus-Iggo) 74-75
Imunelectroforeza 354, 355, 661
Imunitate dobandita 94, 133, 134, 136, 141, 180, 185, 197, 209, 226, 267
Imunitate înnascuta 94, 110t, 132t, 133, 134ft, 136-139, 145, 176, 177, 189, 196, 217, 228, 246f, 247, 422, 425, 449, 455, 487, 501
Imunoablatie 399
Imunoadsorbtia 407
Imunoconglutinine (IK) 308
Imunocromatografia 350-353, 365t
Imunodeficienta/e 283, 290-297, 299-305, 360, 364t, 428, 429
cainelui mexican fara par 302
combinata severa (SCID) 295, 296
primare 291, 364
rasei Weimaraner 300
secundare ale imunitatii celulare 302
secundare ale imunitatii umorale 302
secundare mixte 303
secundare unor cauze fiziologice 303
selectiva în IgA 292, 299
selectiva în IgG 293
selectiva în IgM 293
Imunodifuziune 354
Imunofiltrare 350
Imunofluorescenta (IF directa/indirecta) 346, 347, 349, 350, 524, 527, 533, 534, 539, 540, 542-548, 550, 550, 552f-555t, 557-559, 561, 586, 595, 596, 602-604, 622, 636, 640, 641, 648, 654, 657, 663, 664, 669
Imunogen 94, 95, 97, 98, 101, 104-106, 125, 221, 253, 254, 308, 312, 504, 517
Imunoglobuline (Ig) 209, 210, 593
IgA 64, 82, 90, 118, 151, 163-167, 174, 209, 210, 213, 214t, 216, 217t, 218f, 224t, 227, 233, 243, 266, 273, 284, 292-294, 299, 300, 302, 303, 313t, 334t, 364t, 377, 408, 424, 453, 456, 463, 486, 487f, 490, 527, 545-549, 551-553, 558-560, 573t, 581, 595, 596, 604, 628, 629, 657
IgAs 90, 213, 217, 218, 293, 463
IgD 151, 163, 166, 210, 214t-216f, 240, 243, 295, 296, 364t
IgE 106-110, 112, 113, 115, 116, 119, 121, 122, 124, 126, 139, 140, 151, 159, 163, 164, 166, 174, 209, 210, 212, 214t, 218, 219f, 224t, 226-231, 233, 238t, 243, 244, 256, 265-269, 271t, 273-275, 277, 289, 295, 296, 346, 348, 358-361t, 364, 365, 369, 370, 375-378, 380, 410, 412, 418, 431, 433, 434, 449, 450, 453-462, 468, 470-474, 477, 478, 485-487, 490-492, 494, 500, 501, 503-505, 548, 548, 549, 558, 575, 630, 633
IgG 29, 31, 38, 82, 91, 107, 113, 115, 118, 119, 124-126, 152, 163-167, 174, 175, 178, 184, 209, 210, 214-218, 224t, 228, 239t-243, 256, 266, 269, 272, 275, 277, 279, 284, 285t, 288, 289, 292-294, 297, 300, 302, 308, 313t, 355, 364t, 369, 375-377, 402, 407, 408, 422-424, 433, 434, 449, 451, 453-455, 457, 470, 477, 487, 490-492, 494, 502, 503, 516-518, 522, 525, 527, 532-535, 539, 540, 542, 546, 548, 550-552, 554, 558-561, 569, 571-573t, 575, 591, 596, 598, 610, 621, 624, 650, 657, 665
IgM 82, 83, 96, 99, 152, 163-167, 178, 209, 210, 212, 214t, 215, 217, 218, 224t, 215, 217, 218, 224t, 227, 240-243, 255, 256, 275, 277, 279, 284, 292-295, 297, 299, 300, 302, 310, 313t, 355, 364t, 425, 449, 450, 487, 516, 525, 527, 548, 550, 552, 554, 558, 572t-574, 591, 596, 598, 607, 621, 650, 658, 663
IgY 209
Imunohistochimie (IHC) 52, 87, 205, 269, 349, 350, 351, 361, 455, 524, 533, 536, 539, 541, 543, 545, 552, 554, 557, 586, 588, 592, 603, 664
Imunolipozomi 222
Imunomarcaj 221, 345
Incontinentia pigmenti 331
Inflamatie 34, 59, 63t, 73, 85, 110, 115, 125, 132t, 133, 135f-137, 139-146, 151, 158, 159, 167, 181, 187-192, 195, 196t, 199, 225, 226, 228, 239, 252, 253, 265-271, 274, 279, 288, 377, 383-386, 398, 410-412, 433, 449, 451, 458, 460-464, 496, 499, 504, 518, 524, 540, 551, 553t-555t, 558, 559, 563-566, 578, 593-598, 602, 604t, 605t, 609, 610, 624, 643, 646-651, 655, 662, 664, 667-669
Inhibitori ai enzimei de conversie a angiotensinei (ACEI) 450, 451
Inhibitorul stafilococic al C (SCIN) 423
Insuficienta hepatica 389
Insuficienta suprarenala 389, 392, 393
Integrine 22, 27, 31, 32, 34, 36, 40, 41, 58, 85, 100t, 142t, 172, 182t, 184, 185, 193, 198, 224t, 230, 233, 235, 297, 301, 449, 556t, 568, 587, 606
Interferoni:
IFN-α 201, 223, 224t, 236, 237, 404, 631, 634, 636, 652
IFN-β 56, 201, 223, 224t, 236, 404, 651
IFN-γ 64, 138, 140, 142t, 164, 166, 172, 174-180, 193, 195, 206, 208, 223-233, 237, 244, 245, 247, 255, 287, 289, 297, 306, 376, 405, 411, 412, 433, 454, 480, 501, 535, 549, 569, 579, 587, 610, 656
IFN-δ 237
IFN-λ 64, 237, 404
IFN-ω 404
Interleukine 224t, 239, 271t, 361, 404, 458, 459, 544
IL-1 16, 32, 34, 58, 59, 62, 63, 74, 140-142ft, 147t, 149, 164, 174, 182, 190, 192, 193, 195, 199, 201, 206, 224t, 225-230, 232, 233-236, 245, 247, 267, 271, 274t, 305, 385t, 386, 404, 413, 418, 428, 455, 479, 480, 516, 519, 535, 549, 563, 569t, 596, 604, 606, 607, 622, 625, 662
IL-2 58, 77, 82, 105, 166, 174, 176-180, 198, 201, 224t, 225-229, 232, 233, 244-246, 252, 255, 287, 302-305, 385t, 395, 399-402, 405, 406, 412t, 418, 433, 455, 501, 516, 578, 596, 606, 631, 632, 652
IL-3 140, 165, 177, 180, 201, 224, 231, 232, 235, 255, 267, 271, 274, 403, 454T, 458, 459
IL-4 59, 138, 140, 146, 149, 164-166, 172, 174-177, 180, 201, 224, 226-231, 237, 238t, 244-247, 266, 267, 274t, 275, 302, 376, 400, 401, 403, 412t, 413, 422, 433, 454, 458, 459, 462, 472, 486, 492, 501, 535, 549, 604, 606
IL-5 158, 159, 164-166, 174, 177, 224, 228-231, 245, 267, 271, 273, 274t, 375, 376, 400, 412, 418, 450, 458, 459, 492, 501, 632-634, 639, 641
IL-6 58, 59, 62, 63t, 140-142, 147t, 165, 166, 177, 190, 192, 201, 221, 224, 226-232, 235, 236, 244, 245, 247, 275, 282, 305, 395, 412t, 418, 450, 459, 479, 480, 516, 519, 544, 563, 596, 606, 656, 665
IL-7 224T, 225, 231, 232, 245, 302
IL-8 62, 63T, 74, 115, 140, 143, 147, 188T, 218, 224T, 231, 236-238T, 267, 271, 273, 274t, 395, 403, 456, 501, 549, 596
IL-9 224t, 225, 229, 302
IL-10 122, 137, 138, 166, 176, 177, 195, 201, 224t, 225, 229-231, 235, 236, 244, 245, 267, 268, 307, 376, 377, 386, 403, 418, 458, 459, 462, 480, 486, 519, 549, 606, 631
IL-11 224, 225, 232
IL-12 64, 110t, 115, 138, 140, 164, 172, 174-176, 179, 180, 193, 195, 198, 201, 224t, 225-233, 244, 245, 255, 406, 413, 433, 480, 519, 604
IL-13 149, 165, 166, 174, 176, 178, 224t, 225, 230, 231, 245, 275, 400, 433, 458, 459, 501, 535, 549, 634
IL-14 224t, 232
IL-15 180, 199, 224t, 225, 230, 232, 245, 302, 549
IL-16 138, 224t, 225, 230, 231, 287
IL-17 224, 225, 230, 237
IL-21 180, 225, 230, 231, 245, 302
IL-23 172, 225, 227, 230, 231
IL-28 225, 231
IL-29 225
IL-30 (IFN-λ) 225, 231
Internexina 47
Intertrigo 334t, 384t
Intoleranta alimentara 118, 483, 484, 490
Involucrina 18, 19, 43-45, 48, 51
Iradierea limfonodulilor 407
Itraconazol 435t-439, 577, 599, 605
Ivermectina 120, 451, 499, 502, 577, 589, 599
Izoanticorpi 584
Izocianati 123, 535
Izotipie 213, 293
Izotretinoin 414, 415, 578, 582, 631, 648, 663
Invelisului celular cornificat 44, 45

J

JAM 35, 182t
Jonctiuni celulare 35
aderente 35, 38-40
de ancorare 34, 35
de comunicare 37
dermo-epidermica 20-22, 347, 543, 548, 549, 551, 553, 557-559, 592, 655, 656
gap 19, 27, 28, 34, 35, 41, 42, 48, 58, 60
ocluzive 35
tight 27, 35-37, 39

K

Kalicreine (prostatatica) 121, 147
Keratina (soft, hard, K2e) 17, 19, 20, 28, 31, 35, 38, 40, 41, 43-45, 47, 49f-52, 56, 67, 70, 71, 77, 233, 340, 345, 415, 647, 656, 664
Keratinizare 3, 15, 17, 19, 20, 49, 50, 68, 71, 415, 418, 437, 464, 646, 647
Keratinocit 15-19, 21, 22, 26, 27, 30-32, 34, 36-38, 41-46, 48-53, 55-59, 62, 64, 71, 74, 78, 79, 89, 101t, 115, 133t, 142t, 143, 187, 198, 203f, 206, 226 -228, 230-238t, 245, 323, 325, 327, 347, 372, 400, 411-414, 420, 431, 433, 434, 453-456, 459, 462, 479-481, 483, 515, 516, 527, 530-533, 539, 540, 543, 544, 547, 548, 550-552, 557, 560, 575, 579-581, 587, 588, 590-592, 597, 606, 607, 610, 623, 628-631, 648, 656, 664, 667-669
Keratinogeneza 43f
Keratocalmina 37
Keratoconjunctivita sicca 402, 404, 630
Keratohialin 20, 43f, 44
Keratoza 320, 321, 336t, 337, 524
Kerion 111, 322, 428, 505f, 578
Ketoconazol (Nizoral) 369, 435t-438
Ketotifen 369t, 411t, 412t
KGF 59, 233
KIR 179
Klebsiella pneumoniae 309

L

L1-CAM 34
Lactoferina 181, 182t, 186, 187, 189, 362t, 425
Lamina bazalis 20, 24
Lamina densa 20-22, 25, 283, 548, 549, 556t-558
Lamina elastica 595, 604
Lamina lucida 20-22, 531, 545, 547-550, 552, 555, 559-661f
Lamina reticularis 20-22
Laminina 5 (LM3A32) 32, 40, 41, 58, 553, 559-561
Laminina-6 (LM3A11) 560
Lampa Wood 333t, 340
Lanturi H 163, 214, 215, 565
Lanturi L 88, 163, 214, 215, 217, 256, 563, 565, 566t
Lanturi grele-γ 572
Lanturi usoare de amiloid (AL) 563
Larva migrans 149, 454, 500
Leading edge 184f
Lectine 98, 141f, 179, 188, 189, 199, 501, 563
Leflunomida 403
Legaturi van der Waals 95
Leishmania spp. 148t, 286t, 501, 643
Lepidoglyphus destructor 115, 498
Leptomeninge 609
Leucafereza/limfafereza 407
LeuCAM 28
Leucemia eozinofilica 632, 633t
Leucemie limfocitara cronica 544t
Leucodermie 496, 627
Leucotoxine 424
Leucotrichie
Leucotriene 117, 143, 144t, 146, 195, 226, 267, 269, 270, 274, 276, 385, 387, 395, 408, 437, 449
Leukocidina (PVL, E/D, M/F-PV-like) 424
Leukosialin 182
Levamisol 120t, 420, 526, 577t, 589t, 636
Levocetirizina 411t, 412
LFA 29t, 32, 173f, 182t, 191
Lichen plan (vezi dermatoze lichenoide)
Lichenificatia 322, 433
Limfadenopatie:
dematopatica 579
infectioasa 88
reactiva 87
Limfocite B (LB) 26, 32, 34, 79, 80, 82-84, 86, 88 -90, 94, 99, 100t, 103-105, 107, 124, 125, 133t, 134, 138, 143, 145, 154, 156, 157, 160-169, 171-174, 178, 180, 185, 196, 197, 200, 201, 205, 206, 209, 213, 214t, 219, 220f, 224t, 226-233, 238t, 240-245, 252, 254-256, 266, 267, 287, 288, 291-296, 300, 302, 303, 305, 306, 308, 310, 312, 313, 345, 351t, 360, 362t, 363, 376, 385t, 398-404, 406, 408, 418, 425, 433, 458, 460-462, 497, 515, 518-520, 526, 563, 565, 566t, 573t, 582, 583, 595, 606, 610, 626, 641, 652, 669
costimularea 164
prezentarea Ag 164
secretia citokinelor 164
Limfocite T (LT) 16, 26, 29t-32, 34, 36, 42, 49, 59, 62, 64, 80-82, 84-90, 94, 99, 100t, 103-105, 110, 124-126, 133t, 134t, 138, 143—146, 156, 160-162, 164-173f, 175, 176, 178, 180, 182t, 187, 193, 196-198, 200, 201, 203-207, 209, 223, 224t, 226-233, 237, 238t, 240-247, 252, 254-256, 265, 267, 269, 274t, 275, 286-296, 299, 300, 302-314, 345, 351t, 362t-364t, 371, 372f, 376, 377, 386, 398-404, 406-408, 411t-413, 418, 425, 433, 449, 453, 457, 458, 459, 461, 468, 479-481, 497, 500, 501, 503, 515, 516, 518, 519t, 524, 526, 535, 563, 568-570, 582, 583, 588, 592, 595, 597, 600, 607, 608, 610, 621, 625, 626, 628, 630, 632, 639, 646, 647, 649t, 652, 655, 656, 663, 669
citokine costimulatoare 172
de memorie 10t, 105, 161t, 176, 230, 237, 286, 296, 479, 625
inactive (resting T-cells) 103
LTa (amplificatoare) 168
LTc (citotoxice) 94, 100, 133t, 143, 171, 173, 177, 180, 187, 188, 196, 207, 208, 228-232, 244, 247, 252, 288, 289, 297, 351, 400, 401, 497, 578, 587, 592, 597, 606, 608, 626f, 628
LTdh (delayed hypersensitivity reaction) 177
LTh (helper) 59, 88, 94, 99, 100, 103, 104, 110, 125, 126, 133t, 136, 138, 142t, 149, 151, 164-168, 171-177, 196, 199-201, 206, 207, 226-240, 242-246, 255, 265-267, 273, 286-288, 291, 292, 294, 304, 306, 308, 312, 351t, 362t, 364t, 376, 399, 400, 411t, 412, 418, 433, 454t, 455, 458-460, 462, 468, 471, 474, 480, 486, 487f, 497, 500, 501, 515, 516, 518, 535, 587, 597, 606, 621, 626f, 628, 634
LTs (supresoare) 171, 176, 177, 243, 291, 292, 304, 307f, 362t, 364t, 406, 486, 497, 515, 518
Limfocite γ/δ 176
Limfokine 177, 205t, 223, 286, 364t, 600, 625
Limfom 87, 88, 101t, 272t, 305, 321, 401, 406, 414, 515, 521, 544, 572, 579, 587, 594, 605, 636, 649
epiteliotrop 327, 522, 527, 536, 551, 592
LT 327, 477t, 544t, 649t, 652
non-Hodgkin 406, 544t, 573
Limfonoduli 73, 79-82, 84-90, 103, 133t, 139, 146, 159, 160, 162, 167, 174, 194, 197-200, 202-205, 214, 215, 244, 247, 288, 292-294, 299, 303, 364t, 389, 407, 408, 479, 480f, 570, 631, 665
Limfotactina (XCL1) 143, 144, 287
Lincomicina 420, 427t, 577t, 589
Lipaze 44, 58, 69, 396t, 652, 654
Lipide vasoactive 146, 195
Lipoatrofia 649t
Lipogranulomul sclerozant 649t
Lipooxigenaza-5 146, 395
Lipopolizaharide bacteriene (LPS) 97, 98, 100t, 135, 137, 138f, 140, 147t, 160t, 161t, 181, 188, 193, 199, 201, 223, 231, 239, 242, 279, 286, 412, 456, 641
Liposarcom cu celule rotunde 544t
Lizozim 132, 181, 182t, 187, 203, 221, 305, 351t, 362t, 425, 644, 669
Loricrina 30, 44, 45, 51
L-thyroxina 589t
Luciferaza 352
Lupus eritematos (LE) 514
boala granulomatoasa cronica cu dermatoza LD-like 514t, 529
chilblain 514f, 528, 651
cutanat exfoliativ 336t, 528
cutanat subacut 514, 528, 529
neonatal 514, 529
cutanat vezicular 528, 551
discoid (LED) 283, 318t, 334t, 343t, 402, 409, 415, 520, 521, 522, 524, 526-529, 531, 541-543, 571, 599t, 607, 658, 667
LE-sindrom erithema multiforme like 529
profund 514, 520, 528, 660
sistemic (LES) 87, 168, 228, 230, 251t, 278, 282, 283, 285t, 298, 304, 306, 308, 312, 318t, 319, 334t, 338, 343t, 347, 358, 359, 398-400, 407, 448, 450, 451, 477t, 514-528, 531t, 536, 541-543, 551, 560, 573, 577, 592, 594t, 598-600t, 603, 606, 629, 649, 652, 658, 667, 668
sistemic bulos (LESB) 529, 555t, 560, 561t
tumidus 528, 529

M

Macrofage 22, 26, 28, 29t, 32, 33, 36, 42, 58, 60, 62, 64, 72, 79, 80, 84, 87, 88, 90, 100t, 102, 103, 132-141t, 143, 144, 147,-151, 156, 158, 160, 164, 171-174, 176, 177, 179-183, 187-189, 191-198, 200-203, 205, 206, 208, 210, 213, 222, 223, 224t, 226-234, 236, 239t, 241, 234, 245, 247, 255, 265, 267, 271, 272, 275, 276, 281, 286-290, 296, 297, 304, 305, 308, 345, 351t, 362t, 376, 385t, 386, 387, 400, 404, 407, 408, 412, 413, 418, 428, 449, 460, 480, 483, 499, 501, 504, 515, 519, 520, 562, 563, 568, 587, 588, 590, 592, 595-597, 600, 610, 643, 644, 646, 652, 654, 655, 661, 668t, 669
Macroglobulinemia Waldenström 167, 302, 406, 544t, 572-574, 594t
Macronichie 667
Mactinina 205
Macula 318, 319f, 333t, 339, 464, 475, 482t, 495, 541, 578, 582, 588, 590, 626, 639, 656, 657, 665
MAdCAM-1 29t, 63t, 86
Mal f1 112
Malar rash 521, 523f
Malassezia spp. 432f, 435, 438, 439, 469
M. furfur 112, 434
M. pachydermatis 112, 113, 187, 433, 437, 455, 462
M. sympodialis 112
MAMP 137
Marbofloxacin 427t
Markeri antigenici 97
Masa eritrocitara (PRBC) 584t
Mastita lupica 528
Mastocite 22, 26, 27f, 29t, 42, 56t, 60, 72, 74, 80, 84, 90, 100, 107, 113, 119, 133, 135-141t, 143-147, 158, 159, 166, 182, 213, 214t, 218, 224t, 227, 229-231, 233, 243, 245, 265-277, 280, 287, 341, 342, 351t, 361t, 368, 370, 372f, 375-377, 380, 400, 408, 410, 418, 434, 448-452, 454, 457-460, 471, 474, 478, 483, 485, 492, 497, 500, 501, 504, 518, 533, 548, 549, 575, 576, 596, 599, 607, 630, 632, 638t, 639, 642f, 662-664, 666
Mastocitom 100t, 272t, 283, 321, 418, 452, 477t, 491, 599, 632, 633t, 635
Matricea extracelulara 20, 24, 31, 35, 40f, 59, 190t, 196t, 234, 500, 597
Maduva osoasa 57, 60, 62, 80, 81, 83, 89, 139, 154, 157, 159, 161t, 162, 167, 181, 191, 197, 201, 203, 205, 214, 215, 227, 231, 232, 245, 256, 265, 267, 271, 290-292, 295, 300, 301, 303, 361t, 363, 364t, 385t, 398, 399, 403, 406, 407, 425, 458, 522, 605, 608t, 631, 633, 634, 652, 665
MBL 152, 153f, 188-190t, 194, 284, 422, 519
M-CAM 34
MCHR1 626
MCP-1 (CCL2) 62, 137, 140, 143, 233, 237, 238t, 247, 271
M-CSF 225, 232
Medrol 396t
Megaesofag 571
Megakariocite 157, 224t, 232
Megestrolacetat 636
Melanina 17, 44, 52, 54, 55, 67, 236, 318, 319f, 483
Melanocite 16f, 17, 21, 22, 26, 30, 32, 34, 35, 37, 42, 43, 52, 53t, 55f, 56t, 61f, 72, 77-79, 234-236, 297, 319, 320f, 342, 351t, 608, 609, 622, 626f-628, 656
Melanodermie 336t, 496, 623f
Melanogeneza 15, 53, 54, 235, 236
Melanozomi 17, 43, 52-56, 235, 627, 628
Melatonina 78, 235, 247
Membrana bazala 16f, 17, 21, 22, 24, 25, 40, 41-43, 52, 53, 56, 60, 64, 65, 72, 73, 79f, 97, 183, 279, 282, 283, 309, 323, 324, 351t, 471, 515, 518, 531, 545, 548, 549, 551, 552, 554, 556, 558, 559t, 598, 603, 621
Membrana nictitans 66
Membrana vitroasa 68
Memorie imunologica 162, 178, 240
Mercaptobenzatiazol 123
Mercaptopurina 397, 398
Meropenem 119
Metastazare 29, 33, 34, 60, 180, 236, 304, 320, 403, 405
Metilprednisolon 387, 388, 390-392, 477, 495, 496, 636, 661
Metoda Graham-Knoll 362t
Metoda Maloney 362t
Metotrexat 398, 402, 403, 605, 608, 625, 660
Mezoclone 51
MGSA 56t, 236
Miconazol 435t-438, 481
Microfibrile tubulare 24
Microfilamente (filamante de actina) 43, 44. 48, 53, 196
Microflora 132, 327, 419, 420, 427, 429, 431, 487t
Microsatelitul FH3570 568
Microglii 139, 206
Microhimerism 313
Micronichie 667t
Microtubuli 26, 43, 44, 46-50, 55, 56
Mielom 167, 168, 215, 219, 220f, 302, 355, 564-566t, 572, 573t, 629, 665
Mieloperoxidaze 110, 181, 182t, 186, 301
Milium coloid 663, 664
Mimetismul molecular 308, 309, 312, 575
Minociclina 578
Minoxidil 624
Mincle (Clec4e/Clecsf9) 189
Miofibrile 21, 568
Mip-2 (CXCL2) 143
Misoprostol 415, 472
Mitoza 17-19, 43, 50, 57, 68, 70f, 393, 439, 515, 583
Mixedem 288, 662t
Moartea celulara programata de tip 2 253
Modelarea matricei extracelulare 58
Moesina 519
Molecular mimicry 310
Molecule de adeziune (vezi CAM)
Molecule vasoactive 145, 280
Monoaminoxidaza (MAO) 628
Monocite 26, 29t, 34, 58, 62, 64, 80, 84, 100t, 103, 137, 139, 140, 143-145, 147, 151, 157, 158, 172, 182t, 185, 187t189, 191193, 197-199, 202, 205, 218, 223, 224t, 227, 228, 230-239, 245, 266, 286, 288, 290, 297, 298, 300, 301, 304, 305, 313, 351, 376, 385, 400, 412, 428, 460, 479, 501, 563, 570, 595, 600, 602, 644, 651
Morfea 328, 649t, 658-660
Morfoline 435t
MSH 56t, 77, 235
Mucegaiuri 106, 367, 368t, 378, 429, 436t, 473t, 498
Mucinoza 336t, 662, 663
Mucoase 30, 35, 56, 77. 82, 83f, 89, 118, 122, 123, 132, 145, 146, 149, 203, 214, 217, 218, 292, 293, 297, 299, 200, 307, 312t, 333t, 338, 339, 377, 393, 416, 420, 422, 431, 448, 452, 463, 468, 486, 487t, 500, 541, 543, 545t-548, 550-556, 579, 581, 586-588, 590-592, 627, 635, 644
Mupirocin 636
Murdannia nudiflora 481
Muschiul erector al firului de par 66, 69
Myastenia gravis 168, 279t, 288, 311, 313, 400, 407
Mycobacterium abscessus 643
Mycobacterium vaccae 472
Mycosis fungoides 579, 583

N

NADHP-oxidaza (NOX) 186
Naftifina 439
Naloxona 417
Naltrexona 417
Natamicina 439
N-CAM 33f, 34
Necroliza epidermica toxica (sindromul Lyell, TEN) 581, 586-592
Necroza 88, 118, 148, 151t, 248, 250t, 252, 283, 321-324t, 344t, 372, 378, 413, 420, 483, 494, 498, 528, 529, 543, 558, 588, 590-597, 599, 601-605, 612, 621, 632, 644, 649t-652, 654, 656, 667
Necrobiosis lipoidica 413, 650
Necroza trombovasculara proliferativa a conchiei auriculare 334, 413, 601, 603, 605
Nefropatia cu IgA 284
Neotrombicula autumnalis 340
Neurofibromina (proteina NF1) 41
Neurokinina (A, NK-1) 74, 140, 454
Neurotoxina eozinofilica (EDN) 273, 274t, 361t, 634
Neurotransmitatori 57, 76, 77, 140, 235, 410, 416
Neutrofil 26, 27f, 29t, 31-33, 42, 62,84, 85, 101t, 110, 132t-135, 141t-149, 156-158, 180-189, 191-197, 199, 206, 213, 224, 226, 229-234, 236-239, 243, 266-270, 272, 276, 279-281, 286, 288, 289f, 291t, 296, 300-304, 317t, 323, 341,351t, 361t, 385t, 395, 408, 409, 422-425, 449, 452-455, 458,459, 464, 471, 476, 483, 489, 497, 499, 501, 503, 522, 529, 533, 540-543, 545-554, 558, 559, 561, 563, 578, 580, 581, 587, 592, 595-605, 624, 628-631, 636, 641, 647, 650-654, 661, 666, 668t, 669
Neutropenia rasei Border Colli 301
NF-κB 137
NGF 140, 234, 235
Niacinamida 409, 410, 528, 534, 535, 543, 553, 555, 605, 610, 643, 645, 655, 669
Nistatina 435t, 437
Nociceptori termici 75
Nod-2 (CARD15) 137
Nodozitatea 321
Noduli 77, 149, 204, 321, 325, 341t, 344t, 450, 477t, 492, 495-497, 499, 502, 528, 546, 567, 578, 582, 594, 601, 637, 639, 641, 643, 644, 648-650, 652, 660, 664, 665
dermici 321
hipodermici 321
reumatoizi 649t
hemolimfatici 88

O

Obstructia recurenta a cailor respiratorii 282
Olopatadina 411, 412
Onicalgie 667t
Onicocriptoza 667t
Onicodistrofia lupoida simetrica 667, 668
Onicodistrofie 666, 667
Onicogripoza 667t
Onicoliza 667t
Onicomadeza 550, 570, 624, 667t, 669
Onicomalacie 667t
Onicomicoza 667t
Onicopatie 667t
Onicorexa 667t
Onicoschizie 667t
Opsonine 184, 185, 189, 191, 194, 210, 218, 222, 423, 434
Opsonizare 103, 154, 184, 185, 188t, 189, 194, 213, 215, 279, 298, 300, 308, 360, 518
Orbifloxacin 427t
Ormetoprim – sulfadimetoxina 427t, 589t
Otita externa 119t, 335t, 341t, 420, 465, 467f, 470, 471, 475, 477t, 481, 674
eozinofilica proliferativa 468
idiopatica inflamatorie/hiperplazica 467
Oxacilina 120t, 427t
Oxytalan 21

P

p53 249, 251, 515
PA-1 568
PAF 36, 76, 144-147t, 182, 226, 269, 270t, 273-276, 361t, 461, 462
Pahionichie 667t
PAL 396t
Pancitopenie 168, 298, 606
Paniculita:
eozinofilica 637, 649t, 655
histiocitara citofagica 649t, 651
lipofagica 651
lipomembranoasa 649t
nodulara sterila idiopatica 643
pancreatica 649t, 652, 654
Pansteatita nutritionala felina 643t
Papula 149, 151t, 204, 319, -323, 333t, 339, 341t, 369, 371, 373, 374, 448, 449, 452, 464, 468, 475, 482, 488, 492, 496, 497, 499, 528, 529, 546, 578, 583, 588, 590, 594, 601, 630, 639, 643, 644, 646, 656, 657, 660, 664-666t
Paraclone 51
Paracoccioides brasiliensis 436
Parafenilendiamina 106, 123
Parakeratoza 234, 327, 336t, 343, 464, 471, 521t, 579, 586, 647, 656, 657
Paralizie imunologica 255
Parametazon 391t
Paraproteine 219, 565, 572-574, 629
Parestezie 333t
Paronichie 666, 667t
Patch-test 363, 372f, 474, 457, 459, 471, 483, 635
PDGF 62, 63t, 224t, 234
PECAM-1 29t, 60, 63t, 182t, 195, 606
Pelodera (Rhabditis) strongyloides 482
Pemfaxina 535
Pemfigoid:
anti-p105 550
anti-p200 550
anti-p450 550
bulos 41, 279t, 312t, 314, 350, 522, 536, 543, 545-553t, 557, 559, 561, 581, 667
cutanat localizat 546
mucoaselor/gingivita descuamativa 547
Pemfigoidul cutanat generalizat:
copilariei 546
dishidroziform 546
eritrodermic 546
nodular 546
polimorf 546
pretibial 546
pruriginos
seboreic 546
urticarian 546
vegetant 546
veziculos 546
Pemfigus:
foliaceu 31, 272t, 319, 334t, 477t, 521t, 527, 531t-533, 540, 541f
paraneoplazic 544, 555, 559
pustulos panepidermic 539
vegetant 534, 539
vulgar 120t, 180, 230, 312, 314, 323, 343t, 359, 522, 531, 532, 534-540, 543, 544, 551, 555, 559, 667
Pen ch13 106
Penicilamina 518, 532, 542, 583, 660
Penicilina 98, 119, 120t, 215, 278, 279, 282, 397t, 420, 451t, 532, 535, 577t-579582, 589, 594, 660
Penicillium stoloniferum 398
Pentoxifilina 413, 414, 453, 483, 535, 572, 586, 604, 605, 660, 663
Pentraxine 189, 563
Peptidele POMC 77, 78
Periderm 17
Periplaneta americana 117
Peroxidaza eozinofilelor (EPO) 272, 274t, 361t
Petesii 319, 604t
Phakinina 47
Phl p1 106
Phytopica 472
Pichia pastoris 116
Pielonefrita xantogranulomatoasa 644
Pimecrolimus (ASM 981) 402
Pinocitoza 17, 26, 72, 73, 183, 191, 199, 205, 479
Piodermie 119, 168, 182, 283, 299, 300, 304, 319, 322, 335t, 338, 342, 365, 390, 420, 426, 427, 451t, 460, 461, 464, 470-472, 476, 478, 482, 483, 489, 492, 494, 495, 497-499, 503, 504, 520, 533, 539, 541, 551, 635, 646-648, 654, 666t
Piogranulom 150f, 334t, 344t, 599t, 643, 645, 647, 660
Piritinol 687
Pityriasis rubra pilaris 579
Placa eozinofilica 151t
Placa urticariana 329, 343
Plachete 29t-32, 59, 62, 144t-146, 157, 166, 189, 196t, 232, 234, 267, 275, 279, 282, 285, 296, 301, 361t, 363t, 425, 449, 584t, 585t
Plakofilina 31, 532
Plakoglobina 30, 31, 37, 38f, 532, 535
Plasmaferaza 305, 406, 407, 526
Plasmalema 17
Plasma 84, 147, 151, 157, 181, 188, 276, 414, 417, 451, 516, 584t, 585t
Plasmina 147, 195
Plasmocit 26, 27f, 80, 82, 84, 87, 90, 101t, 125, 148, 151, 156, 161t-168, 209, 210, 214, 215, 217, 219, 224, 227, 231, 240, 254, 256, 278, 291, 292-294, 299, 351t, 408, 433, 463, 471, 486, 492, 515, 518, 526, 527, 529, 543, 563-565, 571, 582, 583, 595, 599, 610, 623, 624, 639-642f, 644, 657, 665, 668t
Plasmocitom 100t, 219, 565, 573, 665
Plasmocitoza 665
Platonichie 667t
Placile Peyer 82, 90, 161, 295
Plectina 40, 44, 543, 549, 550, 555t, 556
PM-1 568
PMEL 54, 55f
Pneumonyssoides caninum 272
Pneumonia cu Pneumocystis a teckelului 302
Pneumopatii de hipersensibilitate 281, 285t
Podocite 283f
Pododermatita plasmocitara felina 599t, 630t, 640
Polen 97, 106, 107, 109, 110, 116, 124, 125, 266, 286, 367, 465, 473, 481, 639
Poliangeita microscopica 593t
Poliarteritis nodosa 151
Poliartrita 285t, 516, 520, 521, 606
Poliene 435
Polimeraza Taq 357
Polimorfism evolutiv 329
Polipeptide vasoactive 147
Polivalenta 95f, 96
Polizaharid de adeziune intercelulara (PIA) 424
Porphyria cutanea tarda 562
Prebiotice 418, 419, 473
Precipitare 279, 280, 353, 355, 572
Prednison/prednisolon 390, 391, 395, 453, 472, 483, 494, 555, 605, 631, 636, 639, 641
Prevotella spp. 420
Prick-prick test 374
Prick-test 121, 363, 364, 369, 373-375, 380, 470, 595
Prion 563-566t
Probiotice 418, 419, 473
Profilina 122t, 456
Proliferare 26, 30, 41, 49, 51, 52, 55-59, 63, 66, 68, 78, 84, 87, 125, 138, 146, 159, 160, 162, 166, 168, 171-174, 176, 180, 188t, 202, 203, 209, 222, 224t, 226-228, 230-238t, 240, 241-245, 249, 251, 252t, 254, 271, 282-284, 301-304, 322, 385t, 395, 398, 400-403, 412t, 414, 415, 418, 433, 454, 458, 459, 464, 515, 539, 566t, 578, 597, 602-607, 660, 663
Promielocit 181, 271
Propagula 430
Propilenglicol 219, 378, 465, 648
Propionibacterium acnes 419
Prostacicline 63t, 146, 395
Prostaglandine 60, 75, 76, 109, 140, 141, 144t, 146, 147t, 205t, 267-270t, 274-276, 361t, 385, 387, 395, 408, 409, 415, 416, 449, 452, 460, 520
Protegrine 188
Proteina/e:
„β barrel” 240f, 424f
A stafilococica 151, 212, 407
Bence-Jones 168, 565, 572, 573, 665
Btk 293
CD44 100t, 158-160t, 203, 226, 351t, 519, 587, 662
C-reactiva (CPR) 189, 190t, 422, 595
de faza acuta 141, 142t, 189, 190t, 191, 227, 230-231, 271, 563
Efb 423
G 174, 237, 423, 569t
hidrolizata 366
HSP 102t, 103, 309, 310
Isd (SdrC, SdrD si SasG) 422, 425
jak 230, 237
Ki-67 (MKI67) 515
mielomatoasa 167
S-100 198, 202
Sbi 423
stafilococica inhibitoare a chemotaxiei 432
STAT 230, 237, 296, 634
totale 396t
Proteozom 208
Prototecoza 436
Prurit: 15, 74-77, 118-121, 188, 235, 269, 270, 331, 333t, 338, 365, 377, 380, 383, 391t, 395, 401, 410, 413-418, 426, 431, 435, 437, 438, 440, 448, 455t, 458, 462, 464, 465, 468-472, 474-478, 482t, 488, 490, 492, 494, 496, 497, 499, 501, 503, 504, 521, 526, 527, 529, 533, 536, 539, 541, 542, 546, 551, 576, 577t, 579, 585, 598, 629, 632, 635, 647, 648, 661-666
Pseudolimfom indus medicamentos 582
Pseudomonas fluorescens 636
Pseudopelada 624
Pseudoporfiria indusa medicamentos 581, 582
Pseudourticarie 452
Psoralen 624
Psoriazis 33, 34, 87, 227, 228, 230, 232-234, 237, 314, 333t, 350, 384t, 399, 403, 411, 415, 456, 579, 625, 650, 667
Pulex iritans 109
Pulex simulans 109
Puls-terapie 398, 399
Purpura 120t, 278, 282, 285t, 330, 333t, 504, 572, 573, 576, 558, 594, 598, 601, 604t, 645
Henoch-Schönlein 151, 284, 298, 593t, 594t, 596, 604
trombocitopenica 406, 585t
vasculara 581
Pustula 323, 324f, 326f, 333t, 339, 341t, 464, 482t, 488, 499, 532, 533, 534, 539-541, 558, 581, 599, 601, 629, 630, 660
Pustuloza eozinofilica sterila 323, 504, 541, 629, 630, 633t

Q

Quinacrina 340, 409

R

RAB38/32 55
Raclajul pielii 340, 341, 665
Radixina 519
RANTES (CCL5) 62, 140, 144, 232, 236, 237, 239, 271, 411t, 454t, 636
Raspuns anticorpic 166, 517
Raspuns imun (RI) 52, 156, 240, 241, 397, 433, 569t
rCtef1 491
Reactii
alergice de contact 287, 479
alergice de infectie 287
alergice de transplant 287
anafilactoide 107, 275, 277, 370, 416, 576
de autosensibilizare 113, 287
de faza tarzie 269
în lant a polimerazei (PCR) 342, 357, 358, 455, 643, 645
farmacologica 484, 574
gazda contra grefa 104
grefa contra gazda (GVHD) 104, 226, 232, 245, 294-296, 313, 347, 418, 587, 597, 605-608t, 658, 661
inflamatorie acuta imediata 269
metabolica 484
tuberculinica 286, 287
Reactii medicamentoase 338, 477, 632
buloase 581
eczematoase 580
fixe 577t, 579
granulomatoase 581
ihtioziforme 582
lichenoide 577
pseudolimfomatoase 582
psoriaziforme
pustuloase 581
tip LE 583
Reagine (vezi IgE)
Receptori 16, 25, 31, 32, 45, 56-58, 60, 64, 74-81, 86, 94, 97, 99, 105, 110, 132t, 134, 135, 140, 143t, 145-147, 152, 156, 161t, 165, 171, 174, 178-185, 191—193, 196-200, 209, 214, 214, 218, 221-223, 225-228, 231-237t, 240, 243, 247, 249, 252t-256, 265-270t, 273-276, 288, 289, 297, 302, 306, 362t-364t, 389, 404, 405, 410-414, 416, 417, 420, 422-424, 449, 456, 457, 459-462, 532, 549, 582, 600, 607
BCR 100t, 105, 161t, 162-167, 169, 170, 178, 223, 242, 243, 255, 256
costimulatori 171
PAMP 94, 135, 137, 140, 223
TCR 36, 81, 100t, 105f, 161t, 163-166, 169-173, 175, 176, 178, 208, 223, 254, 255, 266, 293, 310, 583, 587, 625, 626,t, 647
Toll-like (TLR) 64, 132t, 135-138f, 140, 141, 160t,175, 192, 193, 199, 223, 225, 275, 404, 418, 428, 449, 456, 501, 606
Recunoasterea celulei tinta 177, 178
Reglarea imuna 225, 242
Renina 275, 284
Retinal 414
Retinoizi sintetici 414, 648
Retinol 190t, 191t, 414
Reteaua arteriala dermica profunda 72
Reteaua hipodermica supraaponevrotica 71
Reteaua intraepidermica Langerhans 74
Reumatismul articular acut (RAA) 308, 309
Reversie antigenica 96
Rezine 123, 481
Rhodotorula 431, 436
Rhopalurus rochai 118
Ribonucleotid-dismutaza 192
Rifampicina 427t, 438, 582
Rinita alergica 266, 412, 419
Roferon 414
Rozete E 362t, 363
rproDer p1 116f

S

Saccharopolyspora rectivirgula 282
SALT 89, 90
Sarcoidoza 88, 415, 578, 594, 649
Sarcom 203, 544t
Satelitoza 524, 590, 607, 608
Sarcoptes scabiei (scabie) 115, 340
SCF 159, 160t, 224, 235, 236, 271, 454t
SCID legat de cromozomul X 295
Scleroderma neonatorum 649t
Scleroza 328, 333t, 339, 597, 603, 607, 608, 658-660
Scopulariopsis 431
SCORAD 395, 419
Scualeni 435
Scuama 20, 43, 106, 113, 114, 122, 327, 339-341, 368t, 422, 427, 525
lambouri 327
lamelara 327
pitiriazica 327
Seborrhea 464
Secretie holocrina 69, 70f
Secventa NC16A 531t, 545, 548-550, 552-554
Segmente hidrofobe 24
Segmente α-helicoide 24
Selamectina 449, 504
Selectine 27, 29t, 32-36, 60, 63t, 85, 159, 160, 173f, 174, 181, 182t, 188, 226, 267, 297, 363t, 449, 479, 595, 596, 600, 606
Selenopsina A 118
Semimucoase 77
Semnalizarea intracelulara 48, 163
Semnalmente 332, 666t
Semnul lui Nikolsky 339, 536, 539, 541, 551, 590, 592
Senalen-epozidaza 435, 439
Serinproteaze 145, 152, 423, 425, 650
Serotonina 75, 77, 78, 117, 144t, 146, 158, 235, 267, 269, 270t, 274, 287, 361t, 363, 386, 415, 416, 454, 485
Sertolinom 334t, 544
Sialomucine 35
SIBO 299
Simbiotice 418, 429
Simulidae 491, 492
Sindrom/oame 65, 106, 121, 141, 168, 227, 247, 265, 277, 282, 285, 290-292, 294, 296, 298, 300-302, 304, 325, 333t, 373, 375, 416, 438, 448, 490, 494, 495, 498, 499, 502, 504, 514, 521, 542, 558, 576, 578, 581, 586, 590, 592-594, 601, 602, 605, 606, 622t, 624, 631, 639, 643, 663
APECED 311
autoimun poliglandular 621
Chediak Higashi 297, 301, 337, 344t
Churg-Strauss 151, 593t, 594t, 596, 602, 604t, 634
Clarkson 451
Cushing 288, 334t, 369, 394, 395
de suprapunere (overlap diseases) 306, 311, 588
Down 621
Evans 320
feminizant 322, 338
Gleich 450
Goodpasture 278, 399, 406, 407
granulocitopatogen 296
hipereozinofilic (SHE) (canin, felin) 631-634
hipereozinofilice cu manifestari sistemice 630t
hiper-IgM non-X-linkat 529
hipersecretiei IgM (HIGM) 293, 294
IPEX 311
Job 296
lupice incomplete (LEI) 524, 525
mielodisplazic 630
nefrotic 302, 304, 398, 521, 598, 604, 608t
NERDS 450
poliarteritei juvenile 142, 602
Raynaud 528, 529, 667
Schnitzler 574
Sézary 579, 582, 583
Sjögren 312, 448, 572, 594t, 597, 598
Sneddon 597
Stevens-Johnson (SJS) 3447, 559, 586-588, 591, 592
Sweet 578, 650
urticariform 448, 590
uveodermatologic 319, 334t, 527, 555, 608, 610, 611f
Wells 639
Wiskott-Aldrich (WAS) 295, 296, 458
Sinusuri 84, 85f, 88, 650
Sirolimus 402
Sistemul APUD 57
Sistemul coagularii 132t, 147, 151
Sistemul complement (C) 120, 138, 151, 152-153, 189, 190t, 215, 216, 270t, 275, 279, 284, 356, 385, 423, 441, 518, 569t, 575, 596, 598, 610
Sludge 276, 598
Solenopsis invicta 118
Somite 22
Specificitate antigenica 50, 178
Splina 80, 84, 88, 89, 193, 245, 562, 567, 631
Spongioza 30, 71, 323, 464, 471, 478, 536, 539, 540, 544, 547, 579, 581, 583, 599, 607, 630, 636, 668
Sporothrix shenckii 431, 436
Stafilokinaza (Sak) 423-425
Staphylococcus 421f, 453, 471, 504
aureus 105, 138, 422, 461, 462
epidermidis 419, 425
felis 420
pseudintermedius 419, 420, 422
simulans 419
Stem cell factor 56
Stenoza pilorica 484
Stilendiamina 123
Strategii extracorporeale 406, 472
Strat
bazal 17, 18, 30, 43, 45f, 51, 52, 69, 197, 234, 433, 656
cornos 15, 19f, 20, 39, 44, 45f, 50, 70f, 77, 383, 438, 464, 530, 541, 590, 628, 631
germinativ 17, 42, 43, 66, 82, 84, 86
granulos 19, 20, 36, 44, 45f, 70, 72, 239, 540, 541, 657
Henle 67
Huxley 67
intermedium 17
lucidum 16f, 20, 45, 70f, 77
spinos 16f, 17, 19, 37, 43-45f, 51, 67, 71, 74, 197, 234, 323, 483, 530, 657
Straturi pliate-β 562
Streptocidine 188
Streptococi 99, 109, 121t, 285t, 291t, 308, 309f, 419, 420, 469, 578, 594t, 625
Streptomyces hygroscopicus 402
Stres 46, 59, 77, 78, 81, 176, 179, 246, 247, 248f, 249, 310, 369, 370, 416, 425, 451-454, 471, 532, 621, 625, 627
Substanta P 74, 76, 77, 140, 147t, 247, 275, 454, 625
Sudoratia 64, 65
Sufuziuni 319
Suideasia nesbetti 498
Sulfasalazina 409, 534, 542, 583, 605, 629
Superantigeni 105, 121
Superfamilia Ig 27, 33-36, 169
Superoxid-dismutaza 186, 195, 425
Suppela suppellectillium 117
socul anafilactic 98, 121, 392
sunturi arterio-venoase 600

T

Tabanidae 491
TACO 584t, 585t
Tacrolimus 290, 305, 401, 402, 527, 534, 542, 608
Talasemie 605
Talidomida 578
TARC 115, 411t, 412
Tazaroten 414
Teaca epiteliala externa 67
Teaca fibroasa (sacul fibros) 67-69
Tehnici dipstick (bandelete) 352
Tehnici radioimune pentru evaluarea Ag 346
Teobromina 485
Tepoxalina 395, 397
Terbinafina 435t, 436t, 439, 516
Terfenadina 411t, 412
Terminatii nervose libere 74
Termoreglare 15, 71, 79t, 90
Testare i.d. 108, 109, 113, 115, 269, 281, 286, 287, 310, 332, 337, 342, 363, 364, 367-371, 373, 377, 378, 380, 401, 428, 449, 457, 459, 461, 462, 469t, 470, 474, 476-478, 491-497, 502-505, 550, 630, 663
Teste imunologice 345, 533
antiglobulinice 355
Coombs 516, 522, 574
cutanate cu extracte de stafilococi 372
de citotoxicitate 356
de degranulare a bazofilelor 503
de hipersensibilitate cutanata întarziata 371
de legare primara 345, 346, 348, 352
de legare secundara 345, 353
de neutralizare 356
de protectie 356
Knott 502
Latex 356f
pe sisteme vii 345, 356
P-K 113, 369, 457, 474, 504
RAST 346, 363, 364, 375, 471, 477
Testul panglicii (scotch test) 340
Tetraciclina 120t, 340,409,410,428,528, 534, 535, 543, 553, 555, 579, 580, 589, 605, 610, 633t, 643, 645, 648, 655, 669
TGF 52, 56, 59, 60, 63t, 115, 138, 166, 195, 201, 224t, 225, 226, 230-233, 243-245, 252t, 267, 268, 274, 282, 283, 307f, 376, 377, 415, 587, 634, 660, 662
Thaumatopina 118
Thaumetopoea spp. 118
Timoblaste 80
Timocite 80, 81, 100-101t, 104, 228, 231, 254, 401
Timus 79-81, 160-162, 168, 174, 178, 197, 201, 231, 247, 255, 267, 290, 291, 294, 295, 302, 363, 369t, 389, 522, 563
Tioconazol 435, 438
Tiopronina 542
Tiramina 485
Tireotoxicoza 288
Tiroidita autoimuna (Hashimoto) 104, 288, 514, 621
Tirozinaza 52, 54, 55f, 609, 627
Tirozinkinaze 31, 56, 62, 165, 232-236, 255, 292
src 165
lyn 165
syk 165
Timom 344, 364, 544, 633
Titrarea anticorpilor 347, 355
Tityus serrulatus 118
TNF 32, 34, 58-62, 74, 102,t, 103, 115, 138, 140, 141t, 147t, 159, 160t, 166, 171, 174, 177, 179-182, 184, 187, 190, 192, -195, 199, 201, 223-232, 235-337, 245, 247, 249, 252, 267, 271t, 274t, 275, 289f, 305, 385t, 386, 395, 401-405, 412t-414, 418, 428, 455, 479, 483, 515, 516, 519, 535, 579, 587, 588, 592, 595, 596, 604, 606, 607, 622, 625, 629, 652, 656, 662, 664
Toleranta 95, 104, 109, 118, 121, 122, 125, 146, 161t, 168, 200, 201, 206, 233, 241, 242, 244f, 245, 253-256, 265, 268, 293, 294, 305-307f, 310-313, 375, 376, 384, 388, 390, 400, 437, 453, 481, 486, 487t, 492, 493, 500, 516, 520, 586, 606
Tolnaftat 439
Tolypocladium inflatum 399
Tonofibrile 20
Torulopsis glabrata 436
Toxiinfectie alimentara 484
Toxocara spp.149, 303, 490
Toxoplasma gondii 286t, 305, 501
Trachyonychie 622
Tradescantia fluminensis 481
Transcobalamina I 181
Transferina 189, 190t, 362t, 433
Tretinoin 414, 415, 481
Triamcinolon 120t, 387-338t, 390-393, 542, 636, 641, 663
Trichodectes canis 340
Trichograma 341
Trichohialin 621, 624
Trichophyton hyphae 39
Trigliceride 69, 389, 396t, 415, 460, 644, 654
Trimetoprim 427t, 428, 540, 578, 579, 582, 589
Trombina 32, 59, 147, 153, 181, 190t, 239, 276
Tromboflebita 649
Trombospondine 22, 25, 60, 62, 64
Tromboxani 144t, 146, 269, 270t, 274, 395, 520
Tropomiozina 115, 488
Trypanosoma cruzi 308
TSH 79
Tubercul 287, 288, 321, 343
Tumora Castelman 544t
Tumora 167, 168, 205, 219, 220, 242, 245, 249, 251t, 272t, 286t, 304, 311, 322, 324, 330, 332, 334t, 338, 340, 343, 345, 539, 566t, 582
Tyrophagus putrescientiae 115, 117, 498
TYRP1 55f
tesut adipos 25, 26, 71f

U

Ubiquitina 208
Ulcer 148, 149, 319, 321, 322, 324, 325f, 330,333t, 334t, 339, 341t, 344t, 475-478, 488, 494-496, 499, 504, 505, 520, 521, 524-526, 528, 529, 531, 533, 543, 544, 547, 550, 551, 553-560, 567, 570, 573, 574, 577t, 590, 592, 594, 601, 602, 604t, 606-608t, 621, 635-639, 661, 663
Ulcerul indolent felin 346t, 635, 636
Umoarea apoasa 439
Unghii (gheare) 16, 17, 50, 64, 69-71, 428, 439, 536, 540, 554, 556, 601, 608t, 622,627,665-669
Unitate
de activare 152
de atac (complex) 152-155, 548, 596, 610
de recunoastere 152
epidermica de proliferare 43
melanica epidermica 52
Uree 389, 396t
Urocortina 78
Urokinaza 63, 145, 205, 468
Urticacee 109
Urticaria 77, 118, 120t, 121, 123, 227, 282, 284, 320, 328, 350, 409, 448-453, 461, 490, 501, 502, 505, 558, 574, 576, 577t, 580, 584, 590, 601, 603, 650
Urticaria pigmentosa felina 400, 665, 666
Uveita 281, 285t, 400, 608, 609, 610, 644, 658

V

VARL 364, 375, 471
Vasculita 76t, 120t, 278t, 280, 282, 285, 287, 293, 296, 313, 335t, 399, 451, 452, 488, 489, 504, 524, 572-574, 577, 578, 586, 593t, -597, 599-603, 605, 649-654
crioglobulinemica 572, 593t
leucocitoclazica (alergica, LCV) 151, 408, 453, 496, 524, 529, 573t, 574, 581, 593t, 594, 596, 598, 604, 649, 641, 665
urticariana 448-451, 493t
Vasculita cutanata focala/alopecia la locul vaccinarii antirabice 601, 603, 605
Vasculopatia cutanata familiala a cainilor Ciobanesc german 601
Vasculopatia mixta cutanata si glomerulara 599, 601, 603
VCAM-1
Vegetatia (papilomatoza) 322
VEGF 62, 64, 234, 267
Verucozitatea 322
Vezicula 322f, 323, 326f, 333t, 339, 534, 538, 548
interstitiala 322
parenchimatoasa 323
subepidermica 323, 553, 559, 579, 581, 587
Vibice 319
Vimentina 40, 46, 47, 198, 204, 345, 351t
Vincristina 525, 634
Vinculina 34, 39
Virbagen Omega 404
Virusul Coxackie 312
Virusul Epstein-Barr 219, 236, 309, 312, 576, 587
Virusul panleucopeniei feline 313, 451, 600
Vitiligo 234, 314, 319, 330, 333t-337t, 340, 344t, 527, 608, 609, 621, 626-628f
Vitronectina 25, 32, 58, 420
VLA 29t, 31, 100t, 159, 173f, 198, 203, 596

W

Western blott 112, 348, 349, 558, 561, 562
Wolbachia spp. 501

X

Xantom (xantogranulom) 344t, 643, 644, 649t

Z

Z01 36
Zona
bazala 20, 68, 552
conjuncta 20
de echivalenta 353
disjuncta 20
Grenz 645, 664
infrabazala 20
suprabazala 20
Zonula adherens 35
Zygomycota 429